Tumors are composed of non-homogeneous cell populations exhibiting varying degrees of
genetic and functional heterogeneity. Cancer stem cells (CSCs) are capable of sustaining …

In this review, we summarize published findings on the involvement of HOX genes in
oncogenesis. HOX genes are developmental genes—they code for proteins that function as …

Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Cancer stem cells (CSCs) are a small population of malignant cells that induce tumor onset
and development. CSCs share similar features with normal stem cells in the case of self …

The homeobox domain transcription factor NANOG, a key regulator of embryonic
development and cellular reprogramming, has been reported to be broadly expressed in …

Abstract The transcription factor Yin Yang 1 (YY1) is frequently overexpressed in cancerous
tissues compared to normal tissues and has regulatory roles in cell proliferation, cell …

It is a commonly held belief that infiltration of immune cells into tumor tissues and direct
physical contact between tumor cells and infiltrated immune cells is associated with physical …

Ovarian cancer is the deadliest gynecological malignancy. It is typically diagnosed at
advanced stages of the disease, with metastatic sites disseminated widely within the …

Metabolic reprogramming is a common phenomenon in cancers. Thus, glycolytic enzymes
could be exploited to selectively target cancer cells in cancer therapy. Hexokinase 2 (HK2) …