Autophagy is a highly conserved catabolic process and participates in a variety of cellular
biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B …

Cancer is a multifactorial, multi-stage disease, including complex cascades of signaling
pathways—the cell growth governed by dysregulated and abrupt cell division. Due to the …

Cancer is a challenging problem for the global health community, and its increasing burden
necessitates seeking novel and alternative therapies. Most cancers share six basic …

Nature is the most abundant source for novel drug discovery. Lycorine is a natural alkaloid
with immense therapeutic potential. Lycorine is active in a very low concentration and with …

Publisher Summary This chapter discusses the chemical and biological aspects of
Narcissus alkaloids. Numerous alkaloids have been isolated from Narcissus …

Twenty-two lycorine-related compounds were investigated for in vitro antitumor activity using
four cancer cell lines displaying different levels of resistance to proapoptotic stimuli and two …

Indolizidine alkaloids are chemical constituents isolated from various marine and terrestrial
plants and animals, including but not limited to trees, fungi, ants, and frogs, with a myriad of …

Anthocyanins are naturally occurring reddish pigments that abundant in fruits and
vegetables. To investigate the mechanistic basis for the anti-tumor properties of …

The severe anticancer situation as well as the emergence of multidrug-resistant (MDR)
cancer cells has created an urgent need for the development of novel anticancer drugs with …

The Amaryllidaceae alkaloids represent a large (over 300 alkaloids have been isolated) and
still expanding group of biogenetically related isoquinoline alkaloids that are found …