In vivo and in vitro models of hepatocellular carcinoma: current strategies for translational modeling

GR Romualdo, K Leroy, CJS Costa, GB Prata… - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …

Understanding and improving cellular immunotherapies against cancer: From cell-manufacturing to tumor-immune models

R Ringquist, D Ghoshal, R Jain, K Roy - Advanced Drug Delivery Reviews, 2021 - Elsevier
The tumor microenvironment (TME) is shaped by dynamic metabolic and immune
interactions between precancerous and cancerous tumor cells and stromal cells like …

Current insights into the hepatic microenvironment and advances in immunotherapy for hepatocellular carcinoma

M Zhao, H Huang, F He, X Fu - Frontiers in Immunology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and shows
high global incidence and mortality rates. The liver is an immune-tolerated organ with a …

Role of αVβ3 in prostate cancer: Metastasis initiator and important therapeutic target

L Tang, M Xu, L Zhang, L Qu, X Liu - OncoTargets and therapy, 2020 - Taylor & Francis
In prostate cancer, distant organ metastasis is the leading cause of patient death. Although
the mechanism of malignant tumor metastasis is unclear, studies have confirmed that …

Progression-free survival of a patient with advanced hepatocellular carcinoma treated with adoptive cell therapy using natural killer cells: a case report

G Hong, S Xie, Z Guo, D Zhang, S Ge… - OncoTargets and …, 2022 - Taylor & Francis
Adoptive cell therapy (ACT) is a promising treatment that is considered safe and efficient.
Natural killer (NK) cells play an important role in the innate immune system and destroy …

The Immunoregulatory Effect of Aconite Treatment on H22 Tumor‐Bearing Mice via Modulating Adaptive Immunity and Natural Killer‐Related Immunity

H Wang, X Qi, W Jia, J Yu, K Yang… - Evidence‐Based …, 2023 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and, in its
advanced stages, has a 5‐year survival rate of only 3% to 5%. Despite novel mechanisms …

The effects of Sorafenib and Natural killer cell co-injection in combinational treatment of hepatocellular carcinoma; an in vivo approach

F Hosseinzadeh, J Ai, A Hajifathali… - Pharmacological …, 2022 - Springer
Background Natural killer cells (NKC) and Sorafenib (Sor) are two important agents for the
treatment of hepatocellular carcinoma (HCC). Over the past decade, the interaction of Sor …

CAR НК-терапия: методы активации и экспансии НК-клеток

ПО Фёдорова - Acta Biomedica Scientifica, 2024 - actabiomedica.ru
Аннотация На сегодняшний день терапия Т-клетками с химерным рецептором
антигена (CAR, chimeric antigen receptor) представляет собой эффективный метод …

ИММУННОЕ МИКРООКРУЖЕНИЕ ПРИ ГЕПАТОЦЕЛЛЮЛЯРНОЙ КАРЦИНОМЕ: СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ И РОЛЬ БЛОКАДЫ ИММУННЫХ …

ЕЛ БУЕВЕРОВА, ОЮ ЗОЛЬНИКОВА… - … дом" Русский врач", 2024 - elibrary.ru
Гепатоцеллюлярная карцинома (ГЦК) является наиболее распространенной первичной
злокачественной опухолью печени. Специфичность иммунной микросреды органа …

[PDF][PDF] Role of connexins, pannexins and their channels in liver cancer

K Leroy - 2023 - researchportal.vub.be
Gap junctions allow for direct intercellular communication between neighboring cells via
diffusion of small and hydrophilic molecules and ions. This flux, called GJIC, is crucial for the …