Polo-like kinase 1 (PLK1) plays an important role in a variety of cellular functions, including
the regulation of mitosis, DNA replication, autophagy, and the epithelial–mesenchymal …

Polo-like kinase 1 (Plk1) plays key roles in regulating mitotic processes that are crucial for
cellular proliferation. Overexpression of Plk1 is tightly associated with the development of …

ABSTRACT Introduction Polo Like Kinase 1 (PLK1) is a key regulator of mitosis and its
overexpression is frequently observed in a wide variety of human cancers, while often being …

The treatment of protein flexibility is a major challenge in structure-based drug design
(SBDD)[1, 2] as proteins are dynamic and commonly undergo conformational changes to …

Phosphonopeptides are mimetics of peptides in which phosphonic acid or related
(phosphinic, phosphonous etc.) group replaces either carboxylic acid group present at C …

Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays a key role in the regulation
of the cell cycle. PLK1 is overexpressed in a variety of human tumors, and its expression …

Polo-like kinase 1 (Plk1) is a central regulator of mitosis and has been validated as a target
for antitumor therapy. The polo-box domain (PBD) of Plk1 regulates its kinase activity and …

The early event of microtubule–kinetochore attachment is a critical stage for precise
chromosome segregation. Here we report that NCAPG2, which is a component of the …

Microtubule affinity-regulating kinase 4 (MARK4) is a serine/threonine kinase involved in the
phosphorylation of MAP proteins that regulates microtubule dynamics and abets tumor …

Protein kinases play key roles in regulating human cell biology, but manifold substrates and
functions make it difficult to understand mechanism. We tested whether we could dissect …