Detection of cancer at an early stage when it is still localized improves patient response to
medical interventions for most cancer types. The success of screening tools such as cervical …

Glioblastoma multiforme (GBM) is the most common and aggressive malignant brain tumor
of the central nervous system and has a very poor prognosis. The current standard of care …

Cancer is the second cause of death worldwide, surpassed only by cardiovascular diseases,
due to the lack of early diagnosis, and high relapse rate after conventional therapies …

Engineered biological systems that integrate multi-input sensing, sophisticated information
processing, and precisely regulated actuation in living cells could be useful in a variety of …

The potential of clustered regularly interspaced short palindromic repeats (CRISPR)–
CRISPR associated protein 9 (Cas9)-based therapeutic genome editing is hampered by …

In the human brain, microRNAs (miRNAs) from the microRNA-376 (miR-376) cluster
undergo programmed “seed” sequence modifications by adenosine-to-inosine (A-to-I) …

Glioblastoma is a highly aggressive malignant tumor involving glial cells in the human brain.
We used high-throughput sequencing to comprehensively profile the small RNAs expressed …

Introduction: This review presents recent developments in the use of nonviral vectors and
transfer technologies in cancer gene therapy. Tremendous progress has been made in …

Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a
broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity …

Safe and effective gene therapy approaches require targeted tissue-specific transfer of a
therapeutic transgene. Besides traditional approaches, such as transcriptional and …