Peroxisomes are dynamic organelles that play an essential role in a variety of cellular
catabolic and anabolic metabolic pathways, including fatty acid alpha-and beta-oxidation …

Human peroxisome biogenesis disorders (PBDs) are a heterogeneous group of autosomal
recessive disorders comprised of two clinically distinct subtypes: the Zellweger syndrome …

Peroxisomes are ubiquitous organelles whose dysfunction causes fatal human diseases.
Most peroxisomal enzymes are imported from the cytosol by the receptor PEX5, which …

Peroxisomes are unique among the organelles of the endomembrane system. Unlike other
organelles that derive most if not all of their proteins from the ER (endoplasmic reticulum) …

Peroxisomal import receptors bind their cargo proteins in the cytosol and target them to
docking and translocation machinery at the peroxisomal membrane (reviewed in ref.). The …

Pex5p, which is the import receptor for peroxisomal matrix proteins harboring a type I signal
sequence (PTS1), is mono-and polyubiquitinated in Saccharomyces cerevisiae. We …

The proper distribution of proteins between the cytosol and various membrane-bound
compartments is crucial for the functionality of eukaryotic cells. This requires the cooperation …

Peroxisomal matrix proteins are posttranslationally imported into peroxisomes with the
peroxisome-targeting signal 1 receptor, Pex5. The longer isoform of Pex5, Pex5L, also …

Peroxisomes are vital metabolic organelles that import their lumenal (matrix) enzymes from
the cytosol using mobile receptors. Surprisingly, the receptors can even import folded …

Peroxisomes import folded, even oligomeric, proteins, which distinguishes the peroxisomal
translocation machinery from the well-characterized translocons of other organelles. How …