Malaria has been a major parasitic disease in tropical and subtropical regions and is
estimated to kill between one and two million people (mainly children) every year. Novel anti …

Drugs used for the treatment and prevention of malaria have resistance-related problems,
making them ineffective for monotherapy. If properly associated, many of these antimalarial …

The present study aimed to develop nanocapsules (NCs) loaded with curcumin (CCM) using
different coatings, comparing the effect of these coatings on physicochemical properties of …

Synthesis, and antimalarial and antibacterial activities of marine alkaloids Page 1 226 |
wileyonlinelibrary.com/journal/cbdd Chem Biol Drug Des. 2021;98:226–233. © 2021 John Wiley …

The ocean is the origin of life, with a unique ecological environment, which has given birth to
a wealth of marine organisms. The ocean is an important source of biological resources and …

The development of new antimalarial drugs is urgent to overcome the spread of resistance
to the current treatment. Herein we synthesized the compound 3, a hit-to‑lead optimization of …

Nowadays, the emergence of superbugs is one of the most serious public health problems.
Strains of Staphylococcus aureus and Klebsiella pneumoniae, resistant to many …

N-acylhydrazones are considered privileged structures in medicinal chemistry, being part of
antimicrobial compounds (for example). In this study we show the activity of N …

Thiophenes are heterocyclic compounds containing a five-membered ring with sulphur as
the heteroatom. This class of substances has been shown to have several biological …

The pharmacological potential of drugs must be evaluated to establish their potential
therapeutic benefits and side effects. This evaluation includes assessment of the effects of …