Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Background Diabetes mellitus (DM) is a major public health problem which prevalence is
constantly raising, particularly in low-and middle-income countries. Both diabetes mellitus …

Multiple human population studies have established the concentration of high density
lipoprotein (HDL) cholesterol as an independent, inverse predictor of the risk of having a …

Diabetes mellitus is a multifactorial disease, classically influenced by genetic determinants
of individual susceptibility and by environmental accelerating factors, such as lifestyle. It is …

We examined whether reduced levels of Apolipoprotein AI (apoA-I) in ovarian cancer
patients are causal in ovarian cancer in a mouse model. Mice expressing a human apoA-I …

Plasma levels of high density lipoprotein cholesterol (HDL-C) have long been associated
with protection against cardiovascular disease (CVD) in large populations. However, HDL-C …

Heme is a complex of iron and the tetrapyrrole protoporphyrin IX with essential functions in
aerobic organisms. Heme is the prosthetic group of hemoproteins such as hemoglobin and …

The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic
syndrome. This review reflects the dramatic increase in research on the role of increased …

ApoA-I—the main apolipoprotein constituent of the HDL (high-density lipoprotein) fraction of
human plasma—is of therapeutic interest because it has several cardioprotective functions …

Obesity-mediated metabolic syndrome remains the leading cause of death worldwide.
Among many potential targets for pharmacological intervention, a promising strategy …