[HTML][HTML] Long non-coding RNA and RNA-binding protein interactions in cancer: experimental and machine learning approaches

H Shaath, R Vishnubalaji, R Elango… - Seminars in cancer …, 2022 - Elsevier
Understanding the complex and specific roles played by non-coding RNAs (ncRNAs), which
comprise the bulk of the genome, is important for understanding virtually every hallmark of …

[HTML][HTML] Long non-coding RNAs are involved in alternative splicing and promote cancer progression

J Ouyang, Y Zhong, Y Zhang, L Yang, P Wu… - British Journal of …, 2022 - nature.com
Alternative splicing (AS) is a key process in which precursor RNAs produce different mature
RNAs, and the disorder of AS is a key factor in promoting cancer development. Compared …

[HTML][HTML] LncRNA MILIP links YBX1 to translational activation of Snai1 and promotes metastasis in clear cell renal cell carcinoma

Y Wang, YC Feng, Y Gan, L Teng, L Wang, T La… - Journal of Experimental …, 2022 - Springer
Background Distant metastasis is the major cause of clear cell renal cell carcinoma (ccRCC)-
associated mortality. However, molecular mechanisms involved in ccRCC metastasis …

[HTML][HTML] ITPR1-AS1 promotes small cell lung cancer metastasis by facilitating P21HRAS splicing and stabilizing DDX3X to activate the cRaf-MEK-ERK cascade

Q Zhang, L Zheng, Y Bai, C Su, Y Che, J Xu, K Sun… - Cancer letters, 2023 - Elsevier
The mechanisms underlying the involvement of long non-coding RNAs (lncRNAs) in the
metastasis of small cell lung cancer (SCLC) remain largely unknown. Here, we identified …

The N-Myc-responsive lncRNA MILIP promotes DNA double-strand break repair through non-homologous end joining

PL Wang, L Teng, YC Feng, YM Yue… - Proceedings of the …, 2022 - National Acad Sciences
The protooncoprotein N-Myc, which is overexpressed in approximately 25% of
neuroblastomas as the consequence of MYCN gene amplification, has long been postulated …

[HTML][HTML] LINC00924-induced fatty acid metabolic reprogramming facilitates gastric cancer peritoneal metastasis via hnRNPC-regulated alternative splicing of Mnk2

Q He, C Yang, Z Xiang, G Huang, H Wu, T Chen… - Cell Death & …, 2022 - nature.com
The molecular mechanism underlying gastric cancer (GC) peritoneal metastasis (PM)
remains unclear. Here, we identified LINC00924 as a GC PM-related lncRNA through …

[HTML][HTML] Long non-coding RNAs: Tools for understanding and targeting cancer pathways

GK Pandey, C Kanduri - Cancers, 2022 - mdpi.com
Simple Summary Long non-coding RNA (lncRNA) is a type of RNA molecule that show
striking resemblance to mRNA in terms of synthesis and structure but lacks protein coding …

Mechanisms of non-coding RNA-modulated alternative splicing in cancer

X Wang, J Hua, J Li, J Zhang, EE Dzakah, G Cao… - RNA biology, 2022 - Taylor & Francis
Alternative splicing (AS) is a common and pivotal process for eukaryotic gene expression
regulation, which enables a precursor RNA to produce multiple transcript variants with …

LncRNAs and CircRNAs in cancer

X Yin, H Lin, L Lin, L Miao, J He, Z Zhuo - MedComm, 2022 - Wiley Online Library
It is well known that noncoding RNAs (ncRNAs) cannot encode proteins, but they can play
important regulatory roles in tumors by combining with proteins, RNAs, and DNAs. As more …

[HTML][HTML] E2F transcription factor 2-activated DLEU2 contributes to prostate tumorigenesis by upregulating serum and glucocorticoid-induced protein kinase 1

P Li, H Xu, L Yang, M Zhan, Y Shi, C Zhang… - Cell death & …, 2022 - nature.com
Long noncoding RNAs (lncRNAs) participate in biological processes in multiple types of
tumors. However, the regulatory patterns of lncRNAs in prostate cancer remain largely …