Parasites have evolved a wide range of mechanisms that they use to evade or manipulate
the host's immune response and establish infection. The majority of the in vivo studies that …

Prion diseases are rapidly progressive, incurable neurodegenerative disorders caused by
misfolded, aggregated proteins known as prions, which are uniquely infectious. Remarkably …

Individuals infected with prions succumb to brain damage, and prion infections continue to
be inexorably lethal. However, many crucial steps in prion pathogenesis occur in lymphatic …

ABSTRACT α-Synuclein is a soluble, cellular protein that in a number of neurodegenerative
diseases, including Parkinson's disease and multiple system atrophy, forms pathological …

Secondary lymphoid organs (SLO) are underpinned by fibroblastic reticular cells (FRC) that
form dedicated microenvironmental niches to secure induction and regulation of innate and …

Many prion diseases are orally acquired. Our data show that after oral exposure, early prion
replication upon follicular dendritic cells (FDC) in Peyer's patches is obligatory for the …

In neurodegenerative diseases including Alzheimer's, Parkinson's and prion diseases,
astrocytes acquire disease-associated reactive phenotypes. With growing appreciation of …

Prion diseases are transmissible, neurodegenerative disorders associated with misfolding of
the prion protein. Previous studies show that reduction of microglia accelerates central …

Follicular dendritic cells (FDCs) are unique immune cells that contribute to the regulation of
humoral immune responses. These cells are located in the B-cell follicles of secondary …

Prion diseases affect a wide range of mammal species and are caused by a misfolded self-
propagating isoform (PrPSc) of the normal prion protein (PrPC). Distinct strains of prions …