Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Patients with chronic non-malignant pain report impairment of physical and social life along
with psychological state affecting their overall quality of life. The purpose of managing pain …

Animal models are commonly used in the preclinical development of new drugs to predict
the metabolic behaviour of new compounds in humans. It is, however, important to realise …

Abstract Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large
differences in the pharmacokinetics of a number of clinically important drugs. On the basis of …

The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine,
sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

The selective serotonin reuptake inhibitors (SSRIs) have emerged as a major therapeutic
advance in psychopharmacology. As a result, the discovery of these agents marks a …

Background: Tamoxifen, a selective estrogen receptor modulator (SERM), is converted to 4-
hydroxy-tamoxifen and other active metabolites by cytochrome P450 (CYP) enzymes …

Genetic factors contribute to the phenotype of drug response. We systematically analyzed all
available pharmacogenetic data from Medline databases (1970–2003) on the impact that …

We explored whether breast cancer outcomes are associated with endoxifen and other
metabolites of tamoxifen and examined potential correlates of endoxifen concentration …