Receptors of the innate immune system detect conserved determinants of microbial and viral
origin. Activation of these receptors initiates signaling events that culminate in an effective …

Recent advances have provided substantial insight into the maintenance of mucosal
immunity and the pathogenesis of inflammatory bowel disease. Cellular programs …

Alterations of the gut microbiota may cause dysregulated mucosal immune responses
leading to the onset of inflammatory bowel diseases (IBD) in genetically susceptible hosts …

Immunity to pathogens critically requires pattern-recognition receptors (PRRs) to trigger
intracellular signaling cascades that initiate and direct innate and adaptive immune …

Production of the proinflammatory cytokine interleukin 1β (IL-1β) by dendritic cells is crucial
in host defense. Here we identify a previously unknown role for dectin-1 in the activation of a …

Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is
important not only for antigen presentation, but also for the induction of appropriate adaptive …

Myeloid cells are key drivers of physiological responses to pathogen invasion or tissue
damage. Members of the C-type lectin receptor (CLR) family stand out among the …

Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (TFH cells)
is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found …

C-type lectin receptors (CLRs) comprise a heterogeneous group of transmembrane proteins.
Many of them are expressed in myeloid cells and signal in response to pathogen-derived or …

Innate sensors play a critical role in the early innate immune responses to invading
pathogens through sensing of diverse biochemical signatures also known as pathogen …