Activation and role of astrocytes in ischemic stroke

XY Shen, ZK Gao, Y Han, M Yuan, YS Guo… - Frontiers in cellular …, 2021 - frontiersin.org
Ischemic stroke refers to the disorder of blood supply of local brain tissue caused by various
reasons. It has high morbidity and mortality worldwide. Astrocytes are the most abundant …

The influence of neuroinflammation in Autism Spectrum Disorder

SM Matta, EL Hill-Yardin, PJ Crack - Brain, behavior, and immunity, 2019 - Elsevier
Abstract Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised
by deficits in social communication and restricted or repetitive behaviours. The clinical …

Astrocytes: a central element in neurological diseases

M Pekny, M Pekna, A Messing, C Steinhäuser… - Acta …, 2016 - Springer
The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …

Astrocyte reactivity and reactive astrogliosis: costs and benefits

M Pekny, M Pekna - Physiological reviews, 2014 - journals.physiology.org
Astrocytes are the most abundant cells in the central nervous system (CNS) that provide
nutrients, recycle neurotransmitters, as well as fulfill a wide range of other homeostasis …

Glial contributions to neurodegeneration in tauopathies

CEG Leyns, DM Holtzman - Molecular neurodegeneration, 2017 - Springer
Tauopathies are a broad set of neurodegenerative dementias characterized by aggregation
of the tau protein into filamentous inclusions that can be found in neurons and glial cells …

Hollow prussian blue nanozymes drive neuroprotection against ischemic stroke via attenuating oxidative stress, counteracting inflammation, and suppressing cell …

K Zhang, M Tu, W Gao, X Cai, F Song, Z Chen… - Nano …, 2019 - ACS Publications
Ischemic stroke is a devastating disease and one of the leading causes of mortality
worldwide. Overproduction of reactive oxygen and nitrogen species (RONS) following …

New insights into glial scar formation after spinal cord injury

AP Tran, PM Warren, J Silver - Cell and tissue research, 2022 - Springer
Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …

The dual role of astrocyte activation and reactive gliosis

M Pekny, U Wilhelmsson, M Pekna - Neuroscience letters, 2014 - Elsevier
Astrocyte activation and reactive gliosis accompany most of the pathologies in the brain,
spinal cord, and retina. Reactive gliosis has been described as constitutive, graded, multi …

Curcumin—from molecule to biological function

T Esatbeyoglu, P Huebbe, IMA Ernst… - Angewandte Chemie …, 2012 - Wiley Online Library
Turmeric is traditionally used as a spice and coloring in foods. It is an important ingredient in
curry and gives curry powder its characteristic yellow color. As a consequence of its intense …

[HTML][HTML] Microglia in Alzheimer's disease: exploring how genetics and phenotype influence risk

A McQuade, M Blurton-Jones - Journal of molecular biology, 2019 - Elsevier
Research into the function of microglia has dramatically accelerated during the last few
years, largely due to recent genetic findings implicating microglia in virtually every …