[HTML][HTML] Cell-penetrating peptides in diagnosis and treatment of human diseases: from preclinical research to clinical application

J Xie, Y Bi, H Zhang, S Dong, L Teng, RJ Lee… - Frontiers in …, 2020 - frontiersin.org
Cell-penetrating peptides (CPPs) are short peptides (fewer than 30 amino acids) that have
been predominantly used in basic and preclinical research during the last 30 years. Since …

[HTML][HTML] Combination of cell-penetrating peptides with nanoparticles for therapeutic application: a review

S Silva, AJ Almeida, N Vale - Biomolecules, 2019 - mdpi.com
Cell-penetrating peptides (CPPs), also known as protein translocation domains, membrane
translocating sequences or Trojan peptides, are small molecules of 6 to 30 amino acid …

[HTML][HTML] Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer's disease: from current to future challenges

A Cano, P Turowski, M Ettcheto, JT Duskey… - Journal of …, 2021 - Springer
Increasing life expectancy has led to an aging population, which has consequently
increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of …

Brain drug delivery and neurodegenerative diseases: Polymeric PLGA-based nanoparticles as a forefront platform

M Pinto, V Silva, S Barreiro, R Silva, F Remião… - Ageing Research …, 2022 - Elsevier
The discovery of effective drugs for the treatment of neurodegenerative disorders (NDs) is a
deadlock. Due to their complex etiology and high heterogeneity, progresses in the …

[HTML][HTML] Cell-penetrating and targeted peptides delivery systems as potential pharmaceutical carriers for enhanced delivery across the blood–brain barrier (BBB)

SM Ghorai, A Deep, D Magoo, C Gupta, N Gupta - Pharmaceutics, 2023 - mdpi.com
Among the challenges to the 21st-century health care industry, one that demands special
mention is the transport of drugs/active pharmaceutical agents across the blood–brain …

Current advances in the development of novel polymeric nanoparticles for the treatment of neurodegenerative diseases

A Cano, E Sanchez-Lopez, M Ettcheto… - …, 2020 - Taylor & Francis
Effective intervention is essential to combat the coming epidemic of neurodegenerative (ND)
diseases. Nanomedicine can overcome restrictions of CNS delivery imposed by the blood …

Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules

S Harilal, J Jose, R Kumar, MK Unnikrishnan… - Brain research …, 2020 - Elsevier
Barriers are the hallmark of a healthy physiology, blood-brain barrier (BBB) being a tough
nut to crack for most of the antigens and chemical substances. The presence of tight …

[HTML][HTML] Active cellular and subcellular targeting of nanoparticles for drug delivery

OK Nag, JB Delehanty - Pharmaceutics, 2019 - mdpi.com
Nanoparticle (NP)-mediated drug delivery (NMDD) for active targeting of diseases is a
primary goal of nanomedicine. NPs have much to offer in overcoming the limitations of …

Protein corona on brain targeted nanocarriers: challenges and prospects

K Jiang, Y Yu, W Qiu, K Tian, Z Guo, J Qian… - Advanced Drug Delivery …, 2023 - Elsevier
Safe and efficient medical therapy for brain diseases is still an unmet clinical need due to
various barriers represented by the blood-brain barrier. Well-designed brain targeted …

[HTML][HTML] Overcoming the cellular barriers and beyond: Recent progress on cell penetrating peptide modified nanomedicine in combating physiological and …

Y Liu, Z Zhao, M Li - Asian Journal of Pharmaceutical Sciences, 2022 - Elsevier
The complex physiological and pathological conditions form barriers against efficient drug
delivery. Cell penetrating peptides (CPPs), a class of short peptides which translocate drugs …