Obligate protozoan parasites of the kinetoplastids and apicomplexa infect human cells to
complete their life cycles. Some of the members of these groups of parasites develop in at …

Artemisinin (ART)-based combination therapies are the most efficacious treatment of
uncomplicated Plasmodium falciparum malaria. Alarmingly, P. falciparum strains have …

Metal and its oxide nanoparticles show ideal pharmacological activity, especially in anti-
tumor therapy. Our previous study demonstrated that cuprous oxide nanoparticles (CONPs) …

A regulated protein turnover machinery in the cell is essential for effective cellular
homeostasis; any interference with this system induces cellular stress and alters the normal …

The antihistamine clemastine inhibits multiple stages of the Plasmodium parasite that
causes malaria, but the molecular targets responsible for its parasite inhibition were …

The proteasome plays a vital role throughout the life cycle as Plasmodium parasites quickly
adapt to a new host and undergo a series of morphologic changes during asexual …

Phosphatidylinositol 3-phosphate (PI (3) P) levels in Plasmodium falciparum correlate with
tolerance to cellular stresses caused by artemisinin and environmental factors. However, PI …

The killer peptide KP is a synthetic decapeptide derived from the sequence of the variable
region of a recombinant yeast killer toxin-like microbicidal single-chain antibody. KP proved …

Malaria continues to be one of the deadliest infectious diseases and a global health
menace. The emergence and spread of drug-resistant strains of malaria parasites have …

Proteostasis, including protein folding mediated by molecular chaperones, protein
degradation, and stress response pathways in organelles like ER (unfolded protein …