Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
Abstract N 6-methyladenosine (m6A) is a chemical modification present in multiple RNA
species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze …
species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze …
Alternative splicing as a regulator of development and tissue identity
FE Baralle, J Giudice - Nature reviews Molecular cell biology, 2017 - nature.com
Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate
vast protein diversity from a limited number of genes. The mechanisms and outcomes of …
vast protein diversity from a limited number of genes. The mechanisms and outcomes of …
RNA mis-splicing in disease
MM Scotti, MS Swanson - Nature Reviews Genetics, 2016 - nature.com
The human transcriptome is composed of a vast RNA population that undergoes further
diversification by splicing. Detecting specific splice sites in this large sequence pool is the …
diversification by splicing. Detecting specific splice sites in this large sequence pool is the …
A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation
We adapted UV CLIP (cross-linking immunoprecipitation) to accurately locate tens of
thousands of m6A residues in mammalian mRNA with single-nucleotide resolution. More …
thousands of m6A residues in mammalian mRNA with single-nucleotide resolution. More …
starBase v2. 0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data
Although microRNAs (miRNAs), other non-coding RNAs (ncRNAs)(eg lncRNAs,
pseudogenes and circRNAs) and competing endogenous RNAs (ceRNAs) have been …
pseudogenes and circRNAs) and competing endogenous RNAs (ceRNAs) have been …
Mechanisms and regulation of alternative pre-mRNA splicing
Y Lee, DC Rio - Annual review of biochemistry, 2015 - annualreviews.org
Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …
regulation of gene expression, providing significant expansion of the functional proteome of …
Context-dependent control of alternative splicing by RNA-binding proteins
XD Fu, M Ares Jr - Nature Reviews Genetics, 2014 - nature.com
Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …
Molecular roles and function of circular RNAs in eukaryotic cells
LM Holdt, A Kohlmaier, D Teupser - Cellular and Molecular Life Sciences, 2018 - Springer
Protein-coding and noncoding genes in eukaryotes are typically expressed as linear
messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances …
messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances …
[HTML][HTML] Alternative splicing in the mammalian nervous system: recent insights into mechanisms and functional roles
B Raj, BJ Blencowe - Neuron, 2015 - cell.com
High-throughput transcriptomic profiling approaches have revealed that alternative splicing
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …
(AS) of precursor mRNAs, a fundamental process by which cells expand their transcriptomic …
[HTML][HTML] Elimination of toxic microsatellite repeat expansion RNA by RNA-targeting Cas9
Microsatellite repeat expansions in DNA produce pathogenic RNA species that cause
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …