The corticospinal tract (CST) plays a major role in cortical control of spinal cord activity. In
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …

Each of the descending pathways involved in motor control has a number of anatomical,
molecular, pharmacological, and neuroinformatic characteristics. They are differentially …

What changes in neural architecture account for the emergence and expansion of dexterity
in primates? Dexterity, or skill in performing motor tasks, depends on the ability to generate …

We used retrograde transneuronal transport of rabies virus from single muscles of rhesus
monkeys to identify cortico-motoneuronal (CM) cells in the primary motor cortex (M1) that …

Neural plasticity--the brain's ability to change in response to normal developmental
processes, experience, and injury--is a critically important phenomenon for both …

An appreciation of the comparative functions of the corticospinal tract is of direct relevance to
the understanding of how results from animal models can advance knowledge of the human …

Infants with possible cerebral palsy (CP) are commonly assumed to benefit from early
diagnosis and early intervention, but substantial evidence for this is lacking. There is no …

Objective: To characterize the development of ipsilateral corticospinal projections from birth
and compare to 1) development of contralateral projections in the same subjects and 2) …

The corticospinal system is the principal motor system for controlling movements that require
the greatest skill and flexibility. It is the last motor system to develop. The pattern of …

The final pattern of the origin and termination of the corticospinal tract is shaped during
development by the balance between projection and withdrawal of axons. In animals …