Double-stranded RNA (dsRNA) is associated with most viral infections—it either constitutes
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …

Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …

Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …

Aging is a major risk factor for many diseases including metabolic syndrome, cancer,
inflammation, and neurodegeneration. Identifying mechanistic common denominators …

Eukaryotic cells must accurately monitor the integrity of the mitochondrial network to
overcome environmental insults and respond to physiological cues. The mitochondrial …

RNA-binding proteins (RBPs) exert a broad range of biological functions. To explore the
scope of RBPs across eukaryotic evolution, we determined the in vivo RBP repertoire of the …

BACKGROUND Genomes are subject to two types of changes: changes to the DNA
sequence, and changes that are epigenetic in nature. Changes to the DNA sequence can …

Activation of the integrated stress response (ISR) by a variety of stresses triggers
phosphorylation of the α-subunit of translation initiation factor eIF2. P-eIF2α inhibits eIF2B …

The ability to sense and respond to infection is essential for life. Viral infection produces
double-stranded RNAs (dsRNAs) that are sensed by proteins that recognize the structure of …

Protein kinase R (PKR) is an immune response protein that becomes activated by double-
stranded RNAs (dsRNAs). PKR overactivation is associated with degenerative diseases with …