The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Correlation between nuclear and cell size, the nucleocytoplasmic ratio, is a cellular
phenomenon that has been reported throughout eukaryotes for more than a century but the …

Cell size varies greatly between cell types, yet within a specific cell type and growth
condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size …

Just as organ size typically increases with body size, the size of intracellular structures
changes as cells grow and divide. Indeed, many organelles, such as the nucleus [1, 2] …

The spatial organization of cells depends on their ability to sense their own shape and size.
Here, we investigate how cell shape affects the positioning of the nucleus, spindle and …

© 2012 Marshall et al; licensee BioMed Central Ltd. This is an Open Access article
distributed under the terms of the Creative Commons Attribution License (http …

Rapid and reductive cell divisions during embryogenesis require that intracellular structures
adapt to a wide range of cell sizes. The mitotic spindle presents a central example of this …

The volume of the cell nucleus varies across cell types and species and is commonly
thought to be determined by the size of the genome and degree of chromatin compaction …

Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption
with increasing organismal size. This is considered a universal law in biology. Here, we …

The mitotic spindle must function in cell types that vary greatly in size, and its dimensions
scale with the rapid, reductive cell divisions that accompany early stages of development …