There are now many reports of human kidney organoids generated via the directed
differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of …

Congenital abnormalities of the kidney and urinary tract (CAKUT) occur in 1 out of 500
newborns, and constitute approximately 20–30% of all anomalies identified in the prenatal …

Generating a precise cellular and molecular cartography of the human embryo is essential
to our understanding of the mechanisms of organogenesis in normal and pathological …

The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …

The mammalian kidney is a complex organ consisting of multiple cell types. We previously
showed that the Six2-expressing cap mesenchyme is a multipotent self-renewing progenitor …

The identity of niche signals necessary to maintain embryonic nephron progenitors is
unclear. Here we provide evidence that Fgf20 and Fgf9, expressed in the niche, and Fgf9 …

Recent advances in the generation of kidney organoids and the culture of primary nephron
progenitors from mouse and human have been based on knowledge of the molecular basis …

While nephron formation is known to be initiated by a mesenchyme-to-epithelial transition of
the cap mesenchyme to form a renal vesicle (RV), the subsequent patterning of the nephron …

The GenitoUrinary Development Molecular Anatomy Project (GUDMAP) is an international
consortium working to generate gene expression data and transgenic mice. GUDMAP …

Abstract In late 2004, an International Consortium of research groups were charged with the
task of producing a high-quality molecular anatomy of the developing mammalian urogenital …