RNA is the fundamental information transfer system in the cell. The ability to follow single
messenger RNAs (mRNAs) from transcription to degradation with fluorescent probes gives …

Recent advancements in single-cell and single-molecule imaging technologies have
resolved biological processes in time and space that are fundamental to understanding the …

Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport
between the cytoplasm and nucleoplasm. However, their large size and dynamic nature …

The nuclear basket attaches to the nucleoplasmic side of the nuclear pore complex (NPC),
coupling transcription to mRNA quality control and export. The basket expands the …

Nuclear pore complexes (NPCs) are membrane-embedded gatekeepers of traffic between
the nucleus and cytoplasm. Key features of the NPC symmetric core have been elucidated …

This review focuses on imaging DNA and single RNA molecules in living cells to define
eukaryotic functional organization and dynamic processes. The latest advances in …

Nuclear retention of incompletely spliced or mature mRNAs emerges as a novel, previously
underappreciated layer of gene regulation, which enables the cell to rapidly respond to …

To determine which transcripts should reach the cytoplasm for translation, eukaryotic cells
have established mechanisms to regulate selective mRNA export through the nuclear pore …

While splicing has been shown to enhance nuclear export, it has remained unclear whether
mRNAs generated from intronless genes use specific machinery to promote their export …

Highlights•RNA localization is highly conserved throughout evolution.•mRNPs regulate
every step of the journey from birth to death.•mRNPs movement is a combination of diffusion …