Nitric oxide (NO), a small gaseous and multifunctional signaling molecule, is involved in the
maintenance of metabolic and cardiovascular homeostasis. It is endogenously produced in …

Cardiovascular diseases (CVDs) have diverse physiopathological mechanisms with
interconnected oxidative stress and inflammation as one of the common etiologies which …

Significance: Hypertension has major health consequences, which is associated with
endothelial dysfunction. Endothelial nitric oxide synthase (eNOS)-produced nitric oxide (NO) …

Hypertension is a multifactorial disease that affects approximately one billion subjects
worldwide and is a major risk factor associated with cardiovascular events, including …

ABSTRACT Arsenic (As), cadmium (Cd), and mercury (Hg) are toxic elements widely
distributed in the environment. Exposure to these elements was attributed to produce …

Mechanism-based therapy centred on the molecular understanding of disease-causing
pathways in a given patient is still the exception rather than the rule in medicine, even in …

Background: Disruption of redox signaling is a common pathophysiological mechanism
observed in several diseases. In hypertension, oxidative stress, resulted either from …

The structural resemblance between the fused imidazopyridine heterocyclic ring system and
purines has prompted biological investigations to assess their potential therapeutic …

Hypertension is a multifactorial disease associated with impaired nitric oxide (NO)
production and bioavailability. In this respect, restoring NO activity by using nitrite and nitrate …

Ageing is a natural ontogenetic phenomenon that entails a decrease in the adaptive
capacity of the organism, as a result of which the body becomes less adaptable to stressful …