Inflammasomes: their role in normal and complicated pregnancies

N Gomez-Lopez, K Motomura, D Miller… - The Journal of …, 2019 - journals.aai.org
Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …

[HTML][HTML] Recent insights on indirect mechanisms in developmental toxicity of nanomaterials

BB Dugershaw, L Aengenheister, SSK Hansen… - Particle and Fibre …, 2020 - Springer
Background Epidemiological and animal studies provide compelling indications that
environmental and engineered nanomaterials (NMs) pose a risk for pregnancy, fetal …

Dihydromyricetin inhibits NLRP3 inflammasome‐dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells

Q Hu, T Zhang, L Yi, X Zhou, M Mi - Biofactors, 2018 - Wiley Online Library
Increasing evidence demonstrates that pyroptosis, pro‐inflammatory programmed cell
death, is linked to atherosclerosis; however, the underlying mechanisms remain to be …

Prospects and hazards of silica nanoparticles: Biological impacts and implicated mechanisms

R Ding, Y Li, Y Yu, Z Sun, J Duan - Biotechnology Advances, 2023 - Elsevier
With the thrive of nanotechnology, silica nanoparticles (SiNPs) have been extensively
adopted in the agriculture, food, cosmetic, and even biomedical industries. Due to the mass …

[HTML][HTML] Transcriptomic profiling reveals differential cellular response to copper oxide nanoparticles and polystyrene nanoplastics in perfused human placenta

S Chortarea, G Gupta, LA Saarimäki… - Environment …, 2023 - Elsevier
The growing nanoparticulate pollution (eg engineered nanoparticles (NPs) or nanoplastics)
has been shown to pose potential threats to human health. In particular, sensitive …

Saturated fatty acids undergo intracellular crystallization and activate the NLRP3 inflammasome in macrophages

T Karasawa, A Kawashima… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Inflammation provoked by the imbalance of fatty acid composition, such as
excess saturated fatty acids (SFAs), is implicated in the development of metabolic diseases …

[HTML][HTML] A perspective on the developmental toxicity of inhaled nanoparticles

KS Hougaard, L Campagnolo, P Chavatte-Palmer… - Reproductive …, 2015 - Elsevier
This paper aimed to clarify whether maternal inhalation of engineered nanoparticles (NP)
may constitute a hazard to pregnancy and fetal development, primarily based on …

[HTML][HTML] Role of the NLRP3 inflammasome in preeclampsia

K Shirasuna, T Karasawa, M Takahashi - Frontiers in endocrinology, 2020 - frontiersin.org
Reproduction involves tightly regulated series of events and the immune system is involved
in an array of reproductive processes. Disruption of well-controlled immune functions leads …

[HTML][HTML] SIRT1 alleviates LPS-induced IL-1β production by suppressing NLRP3 inflammasome activation and ROS production in trophoblasts

S Park, J Shin, J Bae, D Han, SR Park, J Shin, SK Lee… - Cells, 2020 - mdpi.com
Emerging evidence indicates that aberrant maternal inflammation is associated with several
pregnancy-related disorders such as preeclampsia, preterm birth, and intrauterine growth …

[HTML][HTML] NLRP3 activation and its relationship to endothelial dysfunction and oxidative stress: implications for preeclampsia and pharmacological interventions

PR Nunes, SV Mattioli, VC Sandrim - Cells, 2021 - mdpi.com
Preeclampsia (PE) is a specific syndrome of human pregnancy, being one of the main
causes of maternal death. Persistent inflammation in the endothelium stimulates the …