NRF2 as a therapeutic target in neurodegenerative diseases
MS Brandes, NE Gray - ASN neuro, 2020 - journals.sagepub.com
Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …
the pathogenesis of numerous neurodegenerative conditions including among others …
Targeting Nrf2‐Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals
AG Wu, YY Yong, YR Pan, L Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …
Traumatic brain injury: Mechanisms, manifestations, and visual sequelae
SH Rauchman, A Zubair, B Jacob… - Frontiers in …, 2023 - frontiersin.org
Traumatic brain injury (TBI) results when external physical forces impact the head with
sufficient intensity to cause damage to the brain. TBI can be mild, moderate, or severe and …
sufficient intensity to cause damage to the brain. TBI can be mild, moderate, or severe and …
Dissemination of brain inflammation in traumatic brain injury
Traumatic brain injury (TBI) is recognized as a global health problem due to its increasing
occurrence, challenging treatment, and persistent impacts on brain pathophysiology. Neural …
occurrence, challenging treatment, and persistent impacts on brain pathophysiology. Neural …
Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO‐1 signaling pathway in mice
L Xu, Y Gao, M Hu, Y Dong, J Xu… - Fundamental & clinical …, 2022 - Wiley Online Library
Stroke is the leading cause of disability and death. When blood flow is restored after
prolonged ischemia and hypoxia, it leads to excessive production of reactive oxygen …
prolonged ischemia and hypoxia, it leads to excessive production of reactive oxygen …
The role of the transcription factor Nrf2 in Alzheimer's disease: therapeutic opportunities
LM De Plano, G Calabrese, MG Rizzo, S Oddo… - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a common neurodegenerative disorder that affects the elderly.
One of the key features of AD is the accumulation of reactive oxygen species (ROS), which …
One of the key features of AD is the accumulation of reactive oxygen species (ROS), which …
Antioxidant therapies in traumatic brain injury
CK Davis, R Vemuganti - Neurochemistry international, 2022 - Elsevier
Oxidative stress plays a crucial role in traumatic brain injury (TBI) pathogenesis. Reactive
oxygen species (ROS) and reactive nitrogen species (RNS) formed in excess after TBI …
oxygen species (ROS) and reactive nitrogen species (RNS) formed in excess after TBI …
[HTML][HTML] NADPH oxidases in traumatic brain injury–promising therapeutic targets?
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Despite
intense investigation, no neuroprotective agents for TBI have yet translated to the clinic …
intense investigation, no neuroprotective agents for TBI have yet translated to the clinic …
The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein
Ischemic stroke, which is caused by a clot that blocks blood flow to the brain, can be
severely disabling and sometimes fatal. We previously showed that transient focal ischemia …
severely disabling and sometimes fatal. We previously showed that transient focal ischemia …
Therapeutic targeting of microglia mediated oxidative stress after neurotrauma
AN Smith, M Shaughness, S Collier, D Hopkins… - Frontiers in …, 2022 - frontiersin.org
Inflammation is a primary component of the central nervous system injury response.
Traumatic brain and spinal cord injury are characterized by a pronounced microglial …
Traumatic brain and spinal cord injury are characterized by a pronounced microglial …