NRF2 as a therapeutic target in neurodegenerative diseases

MS Brandes, NE Gray - ASN neuro, 2020 - journals.sagepub.com
Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

Targeting Nrf2‐Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals

AG Wu, YY Yong, YR Pan, L Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs the normal
function of the brain seriously. Its clinical symptoms manifest as behavioral impairment …

Traumatic brain injury: Mechanisms, manifestations, and visual sequelae

SH Rauchman, A Zubair, B Jacob… - Frontiers in …, 2023 - frontiersin.org
Traumatic brain injury (TBI) results when external physical forces impact the head with
sufficient intensity to cause damage to the brain. TBI can be mild, moderate, or severe and …

Dissemination of brain inflammation in traumatic brain injury

K Shi, J Zhang, J Dong, FD Shi - Cellular & molecular immunology, 2019 - nature.com
Traumatic brain injury (TBI) is recognized as a global health problem due to its increasing
occurrence, challenging treatment, and persistent impacts on brain pathophysiology. Neural …

Edaravone dexborneol protects cerebral ischemia reperfusion injury through activating Nrf2/HO‐1 signaling pathway in mice

L Xu, Y Gao, M Hu, Y Dong, J Xu… - Fundamental & clinical …, 2022 - Wiley Online Library
Stroke is the leading cause of disability and death. When blood flow is restored after
prolonged ischemia and hypoxia, it leads to excessive production of reactive oxygen …

The role of the transcription factor Nrf2 in Alzheimer's disease: therapeutic opportunities

LM De Plano, G Calabrese, MG Rizzo, S Oddo… - Biomolecules, 2023 - mdpi.com
Alzheimer's disease (AD) is a common neurodegenerative disorder that affects the elderly.
One of the key features of AD is the accumulation of reactive oxygen species (ROS), which …

Antioxidant therapies in traumatic brain injury

CK Davis, R Vemuganti - Neurochemistry international, 2022 - Elsevier
Oxidative stress plays a crucial role in traumatic brain injury (TBI) pathogenesis. Reactive
oxygen species (ROS) and reactive nitrogen species (RNS) formed in excess after TBI …

[HTML][HTML] NADPH oxidases in traumatic brain injury–promising therapeutic targets?

MW Ma, J Wang, KM Dhandapani, R Wang, DW Brann - Redox biology, 2018 - Elsevier
Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Despite
intense investigation, no neuroprotective agents for TBI have yet translated to the clinic …

The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein

TH Kim, SL Mehta, KC Morris-Blanco, AK Chokkalla… - Science …, 2018 - science.org
Ischemic stroke, which is caused by a clot that blocks blood flow to the brain, can be
severely disabling and sometimes fatal. We previously showed that transient focal ischemia …

Therapeutic targeting of microglia mediated oxidative stress after neurotrauma

AN Smith, M Shaughness, S Collier, D Hopkins… - Frontiers in …, 2022 - frontiersin.org
Inflammation is a primary component of the central nervous system injury response.
Traumatic brain and spinal cord injury are characterized by a pronounced microglial …