Integrative analysis of multi-omics data for discovery and functional studies of complex human diseases

YV Sun, YJ Hu - Advances in genetics, 2016 - Elsevier
Complex and dynamic networks of molecules are involved in human diseases. High-
throughput technologies enable omics studies interrogating thousands to millions of makers …

SNPs: impact on gene function and phenotype

BS Shastry - Single nucleotide polymorphisms: methods and …, 2009 - Springer
Single nucleotide polymorphism (SNP) is the simplest form of DNA variation among
individuals. These simple changes can be of transition or transversion type and they occur …

Sex-specific genetic architecture of human disease

C Ober, DA Loisel, Y Gilad - Nature Reviews Genetics, 2008 - nature.com
Sexual dimorphism in anatomical, physiological and behavioural traits are characteristics of
many vertebrate species. In humans, sexual dimorphism is also observed in the prevalence …

Population-specificity of human DNA methylation

HB Fraser, LL Lam, SM Neumann, MS Kobor - Genome biology, 2012 - Springer
Background Ethnic differences in human DNA methylation have been shown for a number of
CpG sites, but the genome-wide patterns and extent of these differences are largely …

[HTML][HTML] Systematic reviews of animal models: methodology versus epistemology

R Greek, A Menache - International journal of medical sciences, 2013 - ncbi.nlm.nih.gov
Systematic reviews are currently favored methods of evaluating research in order to reach
conclusions regarding medical practice. The need for such reviews is necessitated by the …

Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c

LC Edelstein, LM Simon, RT Montoya, M Holinstat… - Nature medicine, 2013 - nature.com
Racial differences in the pathophysiology of atherothrombosis are poorly understood. We
explored the function and transcriptome of platelets in healthy black (n= 70) and white (n …

Novel susceptibility variants at 10p12. 31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations

H Xu, W Yang, V Perez-Andreu… - Journal of the …, 2013 - academic.oup.com
Background Acute lymphoblastic leukemia (ALL) is the most common cancer in children and
the incidence of ALL varies by ethnicity. Although accumulating evidence indicates inherited …

An overview of cancer health disparities: new approaches and insights and why they matter

TZ Minas, M Kiely, A Ajao, S Ambs - Carcinogenesis, 2021 - academic.oup.com
Cancer health disparities remain stubbornly entrenched in the US health care system. The
Affordable Care Act was legislation to target these disparities in health outcomes. Expanded …

Tissue-specific genetic control of splicing: implications for the study of complex traits

EL Heinzen, D Ge, KD Cronin, JM Maia… - PLoS …, 2008 - journals.plos.org
Numerous genome-wide screens for polymorphisms that influence gene expression have
provided key insights into the genetic control of transcription. Despite this work, the …

Current genetic methodologies in the identification of disaster victims and in forensic analysis

E Ziętkiewicz, M Witt, P Daca, J Żebracka-Gala… - Journal of applied …, 2012 - Springer
This review presents the basic problems and currently available molecular techniques used
for genetic profiling in disaster victim identification (DVI). The environmental conditions of a …