From compulsivity to compulsion: the neural basis of compulsive disorders

TW Robbins, P Banca, D Belin - Nature Reviews Neuroscience, 2024 - nature.com
Compulsive behaviour, an apparently irrational perseveration in often maladaptive acts, is a
potential transdiagnostic symptom of several neuropsychiatric disorders, including …

Leveraging ultra-high field (7T) MRI in psychiatric research

FJ Calabro, AC Parr, VJ Sydnor… - …, 2024 - nature.com
Non-invasive brain imaging has played a critical role in establishing our understanding of
the neural properties that contribute to the emergence of psychiatric disorders. However …

Microviridae bacteriophages influence behavioural hallmarks of food addiction via tryptophan and tyrosine signalling pathways

A Castells-Nobau, I Puig, A Motger-Albertí… - Nature …, 2024 - nature.com
Food addiction contributes to the obesity pandemic, but the connection between how the gut
microbiome is linked to food addiction remains largely unclear. Here we show that …

Highly sensitive determination of l-glutamic acid in pig serum with an enzyme-free molecularly imprinted polymer on a carbon-nanotube modified electrode

XY Yu, JY He, F Tang, P Yu, L Wu, ZL Xiao… - Analytical …, 2023 - pubs.rsc.org
Through electrochemical polymerization using L-glutamic acid (L-Glu) as a template and 4,
6-diaminoresorcinol as a functional monomer, an enzyme-free molecularly imprinted …

Associations of Plasma Glutamatergic Metabolites with Alpha Desynchronization during Cognitive Interference and Working Memory Tasks in Asymptomatic …

VS Leong, J Yu, K Castor, A Al-Ezzi, X Arakaki… - Cells, 2024 - mdpi.com
Electroencephalogram (EEG) studies have suggested compensatory brain overactivation in
cognitively healthy (CH) older adults with pathological beta-amyloid (Aβ42)/tau ratios during …

Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours

HJ Shi, YR Xue, H Shao, C Wei, T Liu, J He, YH Yang… - Brain, 2024 - academic.oup.com
The implication of 5-hydroxytryptamine 2C receptor (5-HT2CR) in depression is a topic of
debate, and the underlying mechanisms remain largely unclear. We now elucidate …

Exploring the role of interleukin-1β and interleukin-6 in the pathophysiology of obsessive-compulsive disorder

N Sarmin, ASM Roknuzzaman, R Sarker, M Rashid… - Plos one, 2024 - journals.plos.org
Background Obsessive-compulsive disorder (OCD) is a highly prevalent neuropsychiatric
disorder. Recently, there has been a growing interest in investigating the association …

High-dose Vitamin-B6 reduces sensory over-responsivity

RO Cracknell, T Tavassoli… - Journal of …, 2024 - journals.sagepub.com
Background: Sensory reactivity differences are experienced by between 5% and 15% of the
population, often taking the form of sensory over-responsivity (SOR), in which sensory …

[HTML][HTML] The promise of N‐acetylcysteine in the treatment of obsessive‐compulsive disorder

M Carollo, N Carollo, G Montan - CNS Neuroscience & …, 2024 - ncbi.nlm.nih.gov
This letter to the Journal is intended to raise awareness within the scientific community about
the potential use of N-acetylcysteine (NAC) as an alternative treatment for obsessive …

New horizons for obsessive-compulsive disorder drug discovery: is targeting glutamate receptors the answer?

G Grassi, E Scillitani, C Cecchelli - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction Over the past decade, glutamate has emerged as a prominent focus in the field
of obsessive-compulsive disorder (OCD) pathophysiology. A convergence of evidence from …