Airway remodeling is a frequent pathological feature of severe asthma leading to permanent
airway obstruction in up to 50% of cases and to respiratory disability. Although structural …

Background Bronchial thermoplasty (BT) has shown favorable safety and efficacy in several
randomized controlled trials (RCTs), but has not been directly compared to biological …

Introduction Bronchial thermoplasty is an effective intervention to improve respiratory
symptoms and to reduce the rate of exacerbations in uncontrolled severe asthma. A …

Airway remodeling (AR) with chronic inflammation, are key features in asthma pathogenesis.
AR characterized by structural changes in the bronchial wall is associated with a specific …

Objective Bronchial thermoplasty (BT) decreases the incidence of asthma exacerbations,
emergency room visits, and hospitalizations among patients with severe asthma. Predictors …

Asthma is a chronic respiratory disease marked by heterogeneity and variable clinical
outcomes. Recent therapeutic advances have highlighted patients achieving optimal …

Severe asthma is a heterogeneous disease encompassing different phenotypes and
endotypes. Although patients with severe asthma constitute a small proportion of the total …

Background Airway remodeling is a prominent feature of asthma, which involves increased
airway smooth muscle mass and altered extracellular matrix composition. Bronchial …

Objectives To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in
treating patients with chronic obstructive pulmonary disease (COPD). Methods Clinical data …

Patient-specific localisation of ventilation defects using hyperpolarised gas magnetic
resonance imaging (MRI) introduces the possibility of regionally targeted bronchial …