Modern medicine has been waging a war on cancer for nearly a century with no tangible
end in sight. Cancer treatments have significantly progressed, but the need to increase …

The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

Helium ion beam therapy for the treatment of cancer was one of several developed and
studied particle treatments in the 1950s, leading to clinical trials beginning in 1975 at the …

Regions of low oxygenation (hypoxia) are a characteristic feature of solid tumors, and cells
existing in these regions are a major factor influencing radiation resistance as well as …

Purpose Late radiation-induced contrast-enhancing brain lesions (CEBLs) on magnetic
resonance imaging (MRI) after proton therapy of brain tumors have been observed to occur …

Proton beam therapy (PBT) offers significant benefit over conventional (photon) radiotherapy
for the treatment of a number of different human cancers, largely due to the physical …

Radiation therapy plays an important role in the multidisciplinary management of breast
cancer. Recent years have seen improvements in breast cancer survival and a greater …

Purpose Present-day treatment planning in carbon ion therapy is conducted with
assumptions for a limited number of tissue types and models for effective dose. Here, we …

Background The purpose of this study was to introduce an experimental radiobiological
setup used for in vivo irradiation of a mouse leg target in multiple positions along a proton …

Dose in proton radiotherapy is generally prescribed by scaling the physical proton dose by a
constant value of 1.1. Relative biological effectiveness (RBE) is defined as the ratio of doses …