Cell types are the basic functional units of an organism. Cell types exhibit diverse
phenotypic properties at multiple levels, making them challenging to define, categorize, and …

Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …

Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA …

INTRODUCTION A mechanistic understanding of brain function requires the identification of
distinct cell types in the brain at a molecular, spatial, and functional level. The preoptic …

Transcriptomics has revealed that cortical inhibitory neurons exhibit a great diversity of fine
molecular subtypes,,,,–, but it is not known whether these subtypes have correspondingly …

The neocortex contains a multitude of cell types that are segregated into layers and
functionally distinct areas. To investigate the diversity of cell types across the mouse …

Oestradiol establishes neural sex differences in many vertebrates 1, 2, 3 and modulates
mood, behaviour and energy balance in adulthood 4, 5, 6, 7, 8. In the canonical pathway …

Glutamate serves as both the mammalian brain's primary excitatory neurotransmitter and as
a key neuromodulator to control synapse and circuit function over a wide range of spatial …

INTRODUCTION Single-cell RNA sequencing has demonstrated that both stable cell types
and transient cell states can be discovered and defined by transcriptomes. In situ …