FTO m6A demethylase in obesity and cancer: implications and underlying molecular mechanisms
Fat mass and obesity-associated protein (FTO) is the first reported RNA N6-
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
methyladenosine (m6A) demethylase in eukaryotic cells. m6A is considered as the most …
[HTML][HTML] Ghrelin
Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …
The bigger picture of FTO—the first GWAS-identified obesity gene
Single nucleotide polymorphisms (SNPs) that cluster in the first intron of fat mass and
obesity associated (FTO) gene are associated obesity traits in genome-wide association …
obesity associated (FTO) gene are associated obesity traits in genome-wide association …
Overexpression of Fto leads to increased food intake and results in obesity
C Church, L Moir, F McMurray, C Girard, GT Banks… - Nature …, 2010 - nature.com
Genome-wide association studies have identified SNPs within FTO, the human fat mass and
obesity–associated gene, that are strongly associated with obesity. Individuals homozygous …
obesity–associated gene, that are strongly associated with obesity. Individuals homozygous …
A link between FTO, ghrelin, and impaired brain food-cue responsivity
E Karra, OG O'Daly, AI Choudhury… - The Journal of …, 2013 - Am Soc Clin Investig
Polymorphisms in the fat mass and obesity-associated gene (FTO) are associated with
human obesity and obesity-prone behaviors, including increased food intake and a …
human obesity and obesity-prone behaviors, including increased food intake and a …
Inactivation of the Fto gene protects from obesity
J Fischer, L Koch, C Emmerling, J Vierkotten, T Peters… - Nature, 2009 - nature.com
Several independent, genome-wide association studies have identified a strong correlation
between body mass index and polymorphisms in the human FTO gene,,,. Common variants …
between body mass index and polymorphisms in the human FTO gene,,,. Common variants …
Current review of genetics of human obesity: from molecular mechanisms to an evolutionary perspective
D Albuquerque, E Stice, R Rodríguez-López… - Molecular genetics and …, 2015 - Springer
It is well-known that obesity is a complex multifactorial and heterogeneous condition with an
important genetic component. Recently, major advances in obesity research emerged …
important genetic component. Recently, major advances in obesity research emerged …
The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives
Mammals expend energy in many ways, including basic cellular maintenance and repair,
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …
digestion, thermoregulation, locomotion, growth and reproduction. These processes can …
The genetics of obesity: FTO leads the way
KA Fawcett, I Barroso - Trends in genetics, 2010 - cell.com
In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and
obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was …
obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was …
Crystal structure of the FTO protein reveals basis for its substrate specificity
Abstract Recent studies,,,, have unequivocally associated the fat mass and obesity-
associated (FTO) gene with the risk of obesity. In vitro FTO protein is an AlkB-like DNA/RNA …
associated (FTO) gene with the risk of obesity. In vitro FTO protein is an AlkB-like DNA/RNA …