Fibro–adipogenic progenitors cross-talk in skeletal muscle: the social network

B Biferali, D Proietti, C Mozzetta, L Madaro - Frontiers in physiology, 2019 - frontiersin.org
Skeletal muscle is composed of a large and heterogeneous assortment of cell populations
that interact with each other to maintain muscle homeostasis and orchestrate regeneration …

[HTML][HTML] Bidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease

W Chen, W You, TG Valencak, T Shan - Ageing Research Reviews, 2022 - Elsevier
Sarcopenia and myopathies cause progressive muscle weakness and degeneration, which
are closely associated with fat infiltration and fibrosis in muscle. Recently, experimental …

Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction

NK Biltz, KH Collins, KC Shen… - The Journal of …, 2020 - Wiley Online Library
Key points Muscle infiltration with adipose tissue (IMAT) is common and associated with loss
of skeletal muscle strength and physical function across a diverse set of pathologies …

[HTML][HTML] Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

J Farup, J Just, F De Paoli, L Lin, JB Jensen… - Cell metabolism, 2021 - cell.com
Type 2 diabetes mellitus (T2DM) is associated with impaired skeletal muscle function and
degeneration of the skeletal muscles. However, the mechanisms underlying the …

Evolving roles of muscle-resident fibro-adipogenic progenitors in health, regeneration, neuromuscular disorders, and aging

M Theret, FMV Rossi, O Contreras - Frontiers in Physiology, 2021 - frontiersin.org
Normal skeletal muscle functions are affected following trauma, chronic diseases, inherited
neuromuscular disorders, aging, and cachexia, hampering the daily activities and quality of …

Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease

G Giuliani, M Rosina, A Reggio - The FEBS journal, 2022 - Wiley Online Library
The characterization of fibro/adipogenic progenitor cells (FAPs) in the skeletal muscle has
contributed to modify the monocentric view of muscle regeneration beyond muscle satellite …

Obesity and the development of lung fibrosis

X Guo, C Sunil, G Qian - Frontiers in pharmacology, 2022 - frontiersin.org
Obesity is an epidemic worldwide and the obese people suffer from a range of respiratory
complications including fibrotic changes in the lung. The influence of obesity on the lung is …

[HTML][HTML] LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis

Y Fang, R Dou, S Huang, L Han, H Fu… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Gastric cancer is anatomically proximal to peritoneum. Gastric cancer peritoneal metastasis
is a complex biological process which is corresponded with disharmony within dysfunctional …

Wound infiltrating adipocytes are not myofibroblasts

S Kalgudde Gopal, R Dai, AM Stefanska… - Nature …, 2023 - nature.com
The origins of wound myofibroblasts and scar tissue remains unclear, but it is assumed to
involve conversion of adipocytes into myofibroblasts. Here, we directly explore the potential …

Cold exposure affects lipid metabolism, fatty acids composition and transcription in pig skeletal muscle

Z Xu, W Chen, L Wang, Y Zhou, Q Nong… - Frontiers in …, 2021 - frontiersin.org
Cold exposure promotes glucose oxidation and modulates the lipid metabolism in adipose
tissue, but it is still not fully clear whether cold exposure could affect meat quality and fatty …