This review is intended to cover the applications of olefin metathesis, with its variations, to
the synthesis and manipulation of peptides and peptidomimetics. The examples presented …

This paper describes an original methodology for peptide bond synthesis avoiding toxic
solvents and reactants. Ball-milling stoichiometric amounts of Boc-protected α-amino acid N …

Synthetically versatile and easy to carry out, Ring‐Closing Metathesis (RCM) constitutes an
attractive chemical tool, easily amenable for multiple substrates in mild conditions. In …

A copper (II) complex of C2-symmetric diamine has been proved to be an efficient catalyst
for the enantioselective Henry reaction between nitroalkanes and various aldehydes to …

Structural mimicry of peptides has witnessed perceptible progress in the last three decades.
Reverse turn and β-hairpin units are the smallest secondary structural motifs that are some …

Cis–trans isomerization of amide bonds plays critical roles in protein molecular recognition,
protein folding, protein misfolding, and disease. Aromatic–proline sequences are particularly …

The design, synthesis, and applications of potential substitutes of t-Bu-PHOX in asymmetric
catalysis is reported. The design relies on the incorporation of geminal substituents at C5 in …

Molecules | Free Full-Text | Structural and Pharmacological Effects of Ring-Closing Metathesis
in Peptides Next Article in Journal Modulation of Huntingtin Toxicity by BAG1 is Dependent on …

As part of a program to identify novel scaffolds that adopt defined secondary structure when
incorporated into peptides, we have designed and prepared a library of constrained eight …

Small peptides having a 3-bromobenzyl group at the C-termini and n-alkynoyl group at the N-
termini undergo a smooth copper-free intramolecular Sonogashira coupling reaction to …