RNA helicase proteins as chaperones and remodelers
I Jarmoskaite, R Russell - Annual review of biochemistry, 2014 - annualreviews.org
Superfamily 2 helicase proteins are ubiquitous in RNA biology and have an extraordinarily
broad set of functional roles. Central among these roles are the promotion of …
broad set of functional roles. Central among these roles are the promotion of …
The eukaryotic RNA exosome
K Januszyk, CD Lima - Current opinion in structural biology, 2014 - Elsevier
Highlights•Eukaryotic exosome cores and phosphorolytic exoribonucleases are structurally
similar.•Exosome cores include a central channel but are catalytically inert.•Central channel …
similar.•Exosome cores include a central channel but are catalytically inert.•Central channel …
Identification of a nuclear exosome decay pathway for processed transcripts
N Meola, M Domanski, E Karadoulama, Y Chen… - Molecular cell, 2016 - cell.com
The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate
targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to RNA-binding protein …
targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to RNA-binding protein …
Noncoding RNA transcription targets AID to divergently transcribed loci in B cells
The vast majority of the mammalian genome has the potential to express noncoding RNA
(ncRNA). The 11-subunit RNA exosome complex is the main source of cellular 3′–5 …
(ncRNA). The 11-subunit RNA exosome complex is the main source of cellular 3′–5 …
The human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis
M Lubas, PR Andersen, A Schein, A Dziembowski… - Cell reports, 2015 - cell.com
The RNA exosome complex constitutes the major nuclear eukaryotic 3′-5′ exonuclease.
Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates …
Outside of nucleoli, the human nucleoplasmic exosome is directed to some of its substrates …
The SKIV2L RNA exosome limits activation of the RIG-I-like receptors
SC Eckard, GI Rice, A Fabre, C Badens, EE Gray… - Nature …, 2014 - nature.com
Sensors of the innate immune system that detect intracellular nucleic acids must be
regulated to prevent inappropriate activation by endogenous DNA and RNA. The …
regulated to prevent inappropriate activation by endogenous DNA and RNA. The …
Human telomerase RNA processing and quality control
The non-coding RNA subunit of telomerase provides the template for telomerase activity. In
diverse fungi, 3′ end processing of telomerase RNA involves a single cleavage by the …
diverse fungi, 3′ end processing of telomerase RNA involves a single cleavage by the …
[HTML][HTML] Helicase-dependent RNA decay illuminated by a cryo-EM structure of a human nuclear RNA exosome-MTR4 complex
EM Weick, MR Puno, K Januszyk, JC Zinder… - Cell, 2018 - cell.com
The ribonucleolytic RNA exosome interacts with RNA helicases to degrade RNA. To
understand how the 3′ to 5′ Mtr4 helicase engages RNA and the nuclear exosome, we …
understand how the 3′ to 5′ Mtr4 helicase engages RNA and the nuclear exosome, we …
The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
C Zorbas, E Nicolas, L Wacheul, E Huvelle… - Molecular biology of …, 2015 - Am Soc Cell Biol
At the heart of the ribosome lie rRNAs, whose catalytic function in translation is subtly
modulated by posttranscriptional modifications. In the small ribosomal subunit of budding …
modulated by posttranscriptional modifications. In the small ribosomal subunit of budding …
EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia
The exosome is a multi-protein complex, required for the degradation of AU-rich element
(ARE) containing messenger RNAs (mRNAs). EXOSC8 is an essential protein of the …
(ARE) containing messenger RNAs (mRNAs). EXOSC8 is an essential protein of the …