The health of children conceived by ART:'the chicken or the egg?'

S Berntsen, V Söderström-Anttila… - Human reproduction …, 2019 - academic.oup.com
Worldwide, more than 7 million children have now been born after ART: these delivery rates
are steadily rising and now comprise 2–6% of births in the European countries. To achieve …

The health outcomes of human offspring conceived by assisted reproductive technologies (ART)

M Chen, LK Heilbronn - Journal of Developmental Origins of Health …, 2017 - cambridge.org
Concerns have been raised about the health and development of children conceived by
assisted reproductive technologies (ART) since 1978. Controversially, ART has been linked …

DNA methylation in newborns conceived by assisted reproductive technology

SE Håberg, CM Page, Y Lee, HE Nustad… - Nature …, 2022 - nature.com
Assisted reproductive technology (ART) may affect fetal development through epigenetic
mechanisms as the timing of ART procedures coincides with the extensive epigenetic …

Epigenetic changes and assisted reproductive technologies

S Mani, J Ghosh, C Coutifaris, C Sapienza, M Mainigi - Epigenetics, 2020 - Taylor & Francis
ABSTRACT Children conceived by Assisted Reproductive Technologies (ART) are at
moderately increased risk for a number of undesirable outcomes, including low birth weight …

In vitro fertilization and adverse obstetric and perinatal outcomes

CS Sullivan-Pyke, S Senapati, MA Mainigi… - Seminars in …, 2017 - Elsevier
Most IVF-conceived children are healthy, but IVF has also been associated with adverse
obstetric and perinatal outcomes as well as congenital anomalies. There is also literature …

Time to take human embryo culture seriously

A Sunde, D Brison, J Dumoulin, J Harper… - Human …, 2016 - academic.oup.com
STUDY QUESTION Is it important that end-users know the composition of human embryo
culture media? SUMMARY ANSWER We argue that there is as strong case for full …

Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood

B Novakovic, S Lewis, J Halliday, J Kennedy… - Nature …, 2019 - nature.com
More than 7 million individuals have been conceived by Assisted Reproductive
Technologies (ART) and there is clear evidence that ART is associated with a range of …

Pregnancy, birth, and infant outcomes by maternal fertility status: the Massachusetts Outcomes Study of Assisted Reproductive Technology

B Luke, D Gopal, H Cabral, JE Stern, H Diop - American journal of …, 2017 - Elsevier
Background Births to subfertile women, with and without infertility treatment, have been
reported to have lower birthweights and shorter gestations, even when limited to singletons …

Oxidative stress and alterations in DNA methylation: two sides of the same coin in reproduction

YJR Menezo, E Silvestris, B Dale, K Elder - Reproductive biomedicine …, 2016 - Elsevier
The negative effect of oxidative stress on the human reproductive process is no longer a
matter for debate. Oxidative stress affects female and male gametes and the developmental …

Epigenetics in the uterine environment: how maternal diet and ART may influence the epigenome in the offspring with long-term health consequences

I Peral-Sanchez, B Hojeij, DA Ojeda… - Genes, 2021 - mdpi.com
The societal burden of non-communicable disease is closely linked with environmental
exposures and lifestyle behaviours, including the adherence to a poor maternal diet from the …