The term ferroptosis was put forward in 2012 and has been researched exponentially over
the past few years. Ferroptosis is an unconventional pattern of iron-dependent programmed …

Transforming growth factor beta (TGF-β) is the most potent pro-fibrogenic cytokine and its
expression is increased in almost all of fibrotic diseases. Although signaling through Smad …

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterized by an
abnormal reepithelialisation, an excessive tissue remodelling and a progressive fibrosis …

Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of
extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary …

Transforming growth factor β (TGF-β) is the most potent and ubiquitous profibrogenic
cytokine, and its expression is increased in almost all the fibrotic diseases and in …

Background Idiopathic pulmonary fibrosis is a chronic progressive disorder with a poor
prognosis. Methods We conducted a double-blind, randomized, placebo-controlled …

Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region
leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants …

Glutathione (γ-glutamyl-cysteinyl-glycine, GSH) is the most abundant intracellular
antioxidant thiol and is central to redox defense during oxidative stress. GSH metabolism is …

Rationale: Tissue fibrosis is considered a dysregulated wound-healing response.
Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of wound …

Nuclear factor-erythroid 2 related factor 2 (Nrf2) is a ubiquitous master transcription factor
that regulates antioxidant response elements (AREs)-mediated expression of antioxidant …