Global epidemiology of systemic lupus erythematosus
MRW Barber, C Drenkard, T Falasinnu, A Hoi… - Nature Reviews …, 2021 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease with protean manifestations
that predominantly affects young women. Certain ethnic groups are more vulnerable than …
that predominantly affects young women. Certain ethnic groups are more vulnerable than …
[HTML][HTML] Digital pathology and computational image analysis in nephropathology
The emergence of digital pathology—an image-based environment for the acquisition,
management and interpretation of pathology information supported by computational …
management and interpretation of pathology information supported by computational …
[HTML][HTML] Genetics of Parkinson's disease: an introspection of its journey towards precision medicine
S Bandres-Ciga, M Diez-Fairen, JJ Kim… - Neurobiology of …, 2020 - Elsevier
ABSTRACT A substantial proportion of risk for Parkinson's disease (PD) is driven by
genetics. Progress in understanding the genetic basis of PD has been significant. So far …
genetics. Progress in understanding the genetic basis of PD has been significant. So far …
[HTML][HTML] Public human microbiome data are dominated by highly developed countries
The importance of sampling from globally representative populations has been well
established in human genomics. In human microbiome research, however, we lack a full …
established in human genomics. In human microbiome research, however, we lack a full …
African genetic diversity and adaptation inform a precision medicine agenda
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …
humans more than 300,000 years ago, has resulted in high genetic diversity and …
[HTML][HTML] From GWAS to gene: transcriptome-wide association studies and other methods to functionally understand GWAS discoveries
B Li, MD Ritchie - Frontiers in Genetics, 2021 - frontiersin.org
Since their inception, genome-wide association studies (GWAS) have identified more than a
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …
hundred thousand single nucleotide polymorphism (SNP) loci that are associated with …
[HTML][HTML] The African genome variation project shapes medical genetics in Africa
Given the importance of Africa to studies of human origins and disease susceptibility,
detailed characterization of African genetic diversity is needed. The African Genome …
detailed characterization of African genetic diversity is needed. The African Genome …
Rare penetrant mutations confer severe risk of common diseases
We examined 454,712 exomes for genes associated with a wide spectrum of complex traits
and common diseases and observed that rare, penetrant mutations in genes implicated by …
and common diseases and observed that rare, penetrant mutations in genes implicated by …
[PDF][PDF] Uganda genome resource enables insights into population history and genomic discovery in Africa
Genomic studies in African populations provide unique opportunities to understand disease
etiology, human diversity, and population history. In the largest study of its kind, comprising …
etiology, human diversity, and population history. In the largest study of its kind, comprising …
H3Africa: current perspectives
N Mulder, A Abimiku, SN Adebamowo… - Pharmacogenomics …, 2018 - Taylor & Francis
Precision medicine is being enabled in high-income countries by the growing availability of
health data, increasing knowledge of the genetic determinants of disease and variation in …
health data, increasing knowledge of the genetic determinants of disease and variation in …