To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Over the last three decades, polymeric micelles have emerged as a highly promising drug
delivery platform for therapeutic compounds. Particularly, poorly soluble small molecules …

Chemotherapy remains a powerful tool to eliminate malignant cells. However, the efficacy of
chemotherapy is compromised by the frequent emergence of intrinsic and acquired …

Recently, diverse functional materials that take subcellular structures as therapeutic targets
are playing increasingly important roles in cancer therapy. Here, particular emphasis is …

Pancreatic ductal adenocarcinoma, as one of the most aggressive cancers, is characterized
by rich desmoplastic stroma that forms a physical barrier for anticancer drugs. To address …

The continuing increase of cancer morbidity and death rate requires efficient therapeutic
strategies. The traditional chemotherapy usually fails to treat cancer or prolong survival rate …

The clinical efficacy of existing cancer therapies is still far from satisfactory. There is an
urgent need to integrate the emerging biomedical discovery and technological innovation …

In view of the multiple pathological hallmarks of tumors, nanosystems for the sequential
delivery of various drugs whose targets are separately located inside and outside tumor …

Inspired by the bionics of marine mussels, polydopamine (PDA), a new polymer with unique
physicochemical properties was discovered. Due to its simple preparation, good …

In recent years, researchers are developing novel nanoparticles for diagnostic applications
using imaging techniques and for therapeutic purposes through drug delivery techniques …