Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways

A Eggel, LF Pennington, TS Jardetzky - Immunological reviews, 2024 - Wiley Online Library
The etiology of allergy is closely linked to type 2 inflammatory responses ultimately leading
to the production of allergen‐specific immunoglobulin E (IgE), a key driver of many allergic …

Contribution of T cell subsets to different food allergic diseases

L Hung, B Zientara, MC Berin - Immunological Reviews, 2024 - Wiley Online Library
Food allergies occur due to a lack of tolerance to the proteins found in foods. While IgE‐and
non‐IgE‐mediated food allergies have different clinical manifestations, epidemiology …

Type 2–polarized memory B cells hold allergen-specific IgE memory

JFE Koenig, NPH Knudsen, A Phelps… - Science Translational …, 2024 - science.org
Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as
allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by …

Irritable bowel syndrome: When food is a pain in the gut

H Hussein, S Van Remoortel… - Immunological …, 2024 - Wiley Online Library
Irritable bowel syndrome (IBS) is a chronic gastrointestinal condition associated with altered
bowel habits and recurrent abdominal pain, often triggered by food intake. Current …

Allergen‐specific B cell responses in oral immunotherapy‐induced desensitization, remission, and natural outgrowth in cow's milk allergy

P Satitsuksanoa, W van de Veen, G Tan, JF Lopez… - Allergy, 2024 - Wiley Online Library
Background Antigen‐specific memory B cells play a key role in the induction of
desensitization and remission to food allergens in oral immunotherapy and in the …

IgE in allergy: It takes two

A von Borstel, RE O'Hehir, MC van Zelm - Science translational …, 2024 - science.org
IgE in allergy: It takes two | Science Translational Medicine news careers commentary
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All roads lead to IgA: Mapping the many pathways of IgA induction in the gut

ER Siniscalco, A Williams… - Immunological …, 2024 - Wiley Online Library
The increasing prevalence of food allergy and related pathologies in recent years has
underscored the need to understand the factors affecting adverse reactions to food. Food …

IgE versus IgG and IgA: Differential roles of allergen‐specific antibodies in sensitization, tolerization, and treatment of allergies

EF Knol, RJJ van Neerven - Immunological reviews, 2024 - Wiley Online Library
The prevalence of asthma, rhinitis, and food allergies has increased dramatically over the
last few decades. This increase originally started in western countries, but is now also …

Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models

A Dejoux, Q Zhu, C Ganneau, ORL Goff… - Science Translational …, 2024 - science.org
Neuromuscular blocking agents (NMBAs) relax skeletal muscles to facilitate surgeries and
ease intubation but can lead to adverse reactions, including complications because of …

Whence and wherefore IgE?

RS Rahman, DR Wesemann - Immunological Reviews, 2024 - Wiley Online Library
Despite the near ubiquitous presence of Ig‐based antibodies in vertebrates, IgE is unique to
mammals. How and why it emerged remains mysterious. IgE expression is greatly …