[HTML][HTML] Biomolecular phase separation: from molecular driving forces to macroscopic properties
Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …
recently been extended to a new class of biomolecules that form liquid-like droplets …
[HTML][HTML] Peptide-based coacervates in therapeutic applications
L Ma, X Fang, C Wang - Frontiers in Bioengineering and …, 2023 - frontiersin.org
Coacervates are droplets formed by liquid‒liquid phase separation. An increasing number
of studies have reported that coacervates play an important role in living cells, such as in the …
of studies have reported that coacervates play an important role in living cells, such as in the …
[HTML][HTML] Members of the Legionella pneumophila Sde family target tyrosine residues for phosphoribosyl-linked ubiquitination
M Zhang, JM McEwen, NM Sjoblom… - RSC Chemical …, 2021 - pubs.rsc.org
Legionella pneumophila establishes a replication vacuole by translocating hundreds of
protein effectors through a type IV secretion system (T4SS). Among these translocated …
protein effectors through a type IV secretion system (T4SS). Among these translocated …
Peptide binder with high-affinity for the SARS-CoV-2 spike receptor-binding domain
Rapid antigen detection tests are urgently needed for the early diagnosis of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). The discovery of a binder with high …
respiratory syndrome coronavirus 2 (SARS-CoV-2). The discovery of a binder with high …
Synthetic neutralizing peptides inhibit the host cell binding of spike protein and block infection of SARS-CoV-2
T Wang, X Fang, T Wen, J Liu, Z Zhai… - Journal of Medicinal …, 2021 - ACS Publications
Antiviral treatments of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
been extensively pursued to conquer the pandemic. To inhibit the viral entry to the host cell …
been extensively pursued to conquer the pandemic. To inhibit the viral entry to the host cell …
Discriminating changes in protein structure using tyrosine conjugation
M Moinpour, NK Barker, LE Guzman, JC Jewett… - Protein …, 2020 - Wiley Online Library
Chemical modification of proteins has been crucial in engineering protein‐based therapies,
targeted biopharmaceutics, molecular probes, and biomaterials. Here, we explore the use of …
targeted biopharmaceutics, molecular probes, and biomaterials. Here, we explore the use of …
[HTML][HTML] A novel CD123-targeted therapeutic peptide loaded by micellar delivery system combats refractory acute myeloid leukemia
S Xu, M Zhang, X Fang, J Meng, H Xing, D Yan… - Journal of Hematology & …, 2021 - Springer
Acute myeloid leukemia (AML) is a common malignant heterogeneous hematopoietic
disease with very low average 5-year survival rate due to the refractory feature and high rate …
disease with very low average 5-year survival rate due to the refractory feature and high rate …
[HTML][HTML] Efficient isolation and quantification of circulating tumor cells in non-small cell lung cancer patients using peptide-functionalized magnetic nanoparticles
N Liang, L Liu, P Li, Y Xu, Y Hou, J Peng… - Journal of Thoracic …, 2020 - ncbi.nlm.nih.gov
Background Circulating tumor cells (CTCs) carry a wealth of information on primary and
metastatic tumors critical for enhancing the understanding of the occurrence, progression …
metastatic tumors critical for enhancing the understanding of the occurrence, progression …
Terminus-immobilization effect on peptide conformations and peptide–peptide interactions
W Luo, X Fang, C Wang, Y Yang, B Tu, Q Fang - Nano Research, 2023 - Springer
Peptide-modified delivery systems are enabling the improvement of the targeting specificity,
biocompatibility, stability, etc. However, the precise design of a peptide-decorated surface …
biocompatibility, stability, etc. However, the precise design of a peptide-decorated surface …
Spatial separation of microbeads into detection levels by a bioorthogonal porous hydrogel for size-selective analysis and increased multiplexity
A Herrmann, S Rödiger, C Schmidt… - Analytical …, 2019 - ACS Publications
Multiplex detection techniques are emerging within the fields of life science research and
medical diagnostics where it is mandatory to analyze a great number of molecules. The …
medical diagnostics where it is mandatory to analyze a great number of molecules. The …