Structural and molecular basis of angiotensin-converting enzyme by computational modeling: Insights into the mechanisms of different inhibitors
L Fang, M Geng, C Liu, J Wang, W Min, J Liu - PloS one, 2019 - journals.plos.org
Angiotensin-I converting enzyme (ACE) is a two-domain dipeptidylcarboxypeptidase
involved in regulating blood pressure via the kallikrein-kininand renin-angiotensin …
involved in regulating blood pressure via the kallikrein-kininand renin-angiotensin …
Cu (II)-TACN complexes selectively induce antitumor activity in HepG-2 cells via DNA damage and mitochondrial-ROS-mediated apoptosis
M Liu, XQ Song, YD Wu, J Qian, JY Xu - Dalton Transactions, 2020 - pubs.rsc.org
A new 1, 4, 7-triazacyclononane derivative, 4-benzyloxy-benzyl-1, 4, 7-triazacyclononane
(btacn), and three associated cyclen complexes, Cu (btacn) Cl2, Zn (btacn) Cl2 and [Cu …
(btacn), and three associated cyclen complexes, Cu (btacn) Cl2, Zn (btacn) Cl2 and [Cu …
Theoretical, antioxidant, antidiabetic and in silico molecular docking and pharmacokinetics studies of heteroleptic oxovanadium(IV) complexes of thiosemicarbazone …
A series of new heteroleptic oxovanadium (IV) complexes with the general formula [VOL1–6
(Dcf)](1–6), where L1− 6= thiosemicarbazone (TSC)-based ligands and Dcf= diclofenac …
(Dcf)](1–6), where L1− 6= thiosemicarbazone (TSC)-based ligands and Dcf= diclofenac …
Multiply intercalator-substituted Cu (II) cyclen complexes as DNA condensers and DNA/RNA synthesis inhibitors
J Hormann, J Malina, O Lemke, MJ Hülsey… - Inorganic …, 2018 - ACS Publications
Many drugs that are applied in anticancer therapy such as the anthracycline doxorubicin
contain DNA-intercalating 9, 10-anthraquinone (AQ) moieties. When Cu (II) cyclen …
contain DNA-intercalating 9, 10-anthraquinone (AQ) moieties. When Cu (II) cyclen …
8-Alkylmercaptocaffeine derivatives: antioxidant, molecular docking, and in-vitro cytotoxicity studies
Due to their unique pharmacological characteristics, methylxanthines are known as
therapeutic agents in a fascinating range of medicinal scopes. In this report, we aimed to …
therapeutic agents in a fascinating range of medicinal scopes. In this report, we aimed to …
Binding forces between a novel Schiff base palladium (II) complex and two carrier proteins: human serum albumi and β-lactoglobulin
S Shahraki, A Heydari - Journal of Biomolecular Structure and …, 2018 - Taylor & Francis
Ligand binding studies on carrier proteins are crucial in determining the pharmacological
properties of drug candidates. Here, a new palladium (II) complex was synthesized and …
properties of drug candidates. Here, a new palladium (II) complex was synthesized and …
Synthesis, characterization and biological assay of three new benzotriazole-based Zn (II) complexes
N Ling, X Wang, D Zeng, YW Zhang, X Fang… - Journal of Molecular …, 2020 - Elsevier
Three new Zn (II) complexes, namely [Zn (emimb) 2 Cl 2](1),[Zn (dmimb) 2 Cl 2](2) and [Zn
(bmem) 2 (SCN) 2](3), have been synthesized using the benzotriazole-based ligands, 1-((2 …
(bmem) 2 (SCN) 2](3), have been synthesized using the benzotriazole-based ligands, 1-((2 …
Metal-free, Mild, and Selective Synthesis of Bis(pyrazolyl)alkanes by Nucleophile-Catalyzed Condensation
M Tansky, Z Gu, RJ Comito - The Journal of Organic Chemistry, 2020 - ACS Publications
Bis (pyrazolyl) alkanes are a prolific class of ligands for catalysis, accessible by the
condensation between bis (pyrazolyl) methanones and carbonyls. In this report, we describe …
condensation between bis (pyrazolyl) methanones and carbonyls. In this report, we describe …
Synthesis, Characterization, Biological Activity, Computational Evaluation and Molecular Docking Simulation of Dimeric Cu (II) Carboxylate Complexes
A Karim, I Akbar, N Ullah, RE Malekshah… - Journal of Molecular …, 2024 - Elsevier
Copper (II) carboxylate complexes are important in biological fields. In this study, five new
dinuclear Cu (II) complexes having the general formulae [Cu 2 (Cl-PAA) 2 (DMSO) 2](1),[Cu …
dinuclear Cu (II) complexes having the general formulae [Cu 2 (Cl-PAA) 2 (DMSO) 2](1),[Cu …
In Silico Evaluation of Food Derived Bioactive Peptides as Inhibitors of Angiotensin Converting Enzyme (ACE)
Hypertension is declared as the major risk factor of cardiovascular diseases and stroke, and
the leading cause of premature deaths. ACE is a zinc dependent dipeptidyl peptidase and …
the leading cause of premature deaths. ACE is a zinc dependent dipeptidyl peptidase and …