The relationships between inflammation and cancer are varied and complex. An important
connection linking inflammation to cancer development is DNA damage. During …

Chagas heart disease is an inflammatory cardiomyopathy that develops in approximately
one-third of people infected with the protozoan parasite Trypanosoma cruzi. One way T …

Chagas disease caused by Trypanosoma cruzi remains an important neglected tropical
disease and a cause of significant morbidity and mortality. No longer confined to endemic …

Autophagic dysfunction is observed in diabetes mellitus. Resveratrol has a beneficial effect
on diabetic cardiomyopathy. Whether the resveratrol‐induced improvement in cardiac …

TNFα is crucially involved in the pathogenesis and progression of myocardial
ischemia/reperfusion injury and heart failure. The formation and release of TNFα and its …

The activation of macrophage respiratory burst in response to infection with Trypanosoma
cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen …

Poly (ADP-ribosyl) ation, attaching the ADP-ribose polymer chain to the receptor protein, is a
unique posttranslational modification. Poly (ADP-ribose) polymerase-1 (PARP-1) is a well …

Trypanosoma cruzi infection leads to development of chronic Chagas disease. In this article,
we provide an update on the current knowledge of the mechanisms employed by the …

PARP family members can be found spread across all domains and continue to be essential
molecules from lower to higher eukaryotes. Poly (ADP‐ribose) polymerase 1 (PARP‐1) …

Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a
critical lack of methods for prevention of infection or treatment of acute infection and chronic …