Schizophrenia is a chronic and severe psychiatric disorder that has profound impact on an
individual's life and on society. Thus, developing more effective therapeutic interventions is …

Identifying biomarkers for major depression is of high importance for improving diagnosis
and treatment of this common and debilitating neuropsychiatric disorder, as the field seeks …

Cognitive functions rely on the coordinated activity of neurons in many brain regions, but the
interactions between cortical areas are not yet well understood. Here we investigated …

N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …

Synchronous recruitment of fast-spiking (FS) parvalbumin (PV) interneurons generates
gamma oscillations, rhythms that emerge during performance of cognitive tasks …

The N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis has been proposed to
help understand the etiology and pathophysiology of schizophrenia. This hypothesis was …

Gamma oscillations appear to be dependent on inhibitory neurotransmission from
parvalbumin (PV)-containing gamma-amino butyric acid neurons. Thus, the abnormalities in …

Activity of parvalbumin-positive hippocampal interneurons is critical for network
synchronization but the receptors involved therein have remained largely unknown. Here we …

A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained
antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that …

Schizophrenia is a psychiatric disorder characterised by symptoms in three domains:
positive (eg delusions, hallucinations), negative (eg social withdrawal, lack of motivation) …