Gastric cancer (GC) is 4th in incidence and mortality rates globally. Several genetic and
epigenetic factors, including microRNAs (miRNAs), affect its initiation and progression …

RNA can be modified by over 170 types of distinct chemical modifications, and the most
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The …

Background Continual expression of PD-L1 in tumor cells is critical for tumor immune
escape and host T cell exhaustion, however, knowledge on its clinical benefits through …

Gastric cancer (GC) is a malignancy with poor prognosis. NDUFA4 is reported to correlate
with the progression of GC. However, its underlying mechanism in GC is unknown. Our …

RNA network control is a key aspect of proper cellular homeostasis. In this context, RNA-
binding proteins (RBPs) play a major role as regulators of the RNA life cycle due to their …

Emerging evidences show RNA back-splicing produces a new type of noncoding RNA,
namely circular RNA (circRNA). Many reports demonstrate that circRNA circHIPK3 exerts …

Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is
associated with tumorigenesis and progression. However, the exact molecular mechanisms …

Background Esophageal squamous cell carcinoma (ESCC) is one of the most common
cancer types and represents a threat to global public health. N6-Methyladenosine (m6A) …

Abstract MicroRNA-34 (miR-34) plays central roles in human diseases, especially cancers.
Inactivation of miR-34 is detected in cancer cell lines and tumor tissues versus normal …

Background N6-methyladenosine (m6A) RNA methylation and tumor immune
microenvironment played crucial roles in cancer development. However, their association in …