Topical products, widely used to manage skin conditions, have evolved from simple potions
to sophisticated delivery systems. Their development has been facilitated by advances in …

Skin's effectiveness as a barrier to permeation of water and other chemicals rests almost
entirely in the outermost layer of the epidermis, the stratum corneum (SC), which consists of …

Lipid molecules are able to selectively interact with specific sites on integral membrane
proteins, and modulate their structure and function. Identification and characterization of …

With the rapid development of computer power and wide availability of modelling software
computer simulations of realistic models of lipid membranes, including their interactions with …

Cell membranes protect and compartmentalise cells and their organelles. The semi‐
permeable nature of these membranes controls the exchange of solutes across their …

The stratum corneum (SC), the outermost layer of skin, represents the primary barrier to
molecules penetrating the skin. Menthol is widely used in clinical medicine as a penetration …

Recent studies in lipid raft formation and stratum corneum permeability have focused on the
role of ceramides (CER). In this study, we use the all-atom CHARMM36 (C36) force field to …

Lipid/water interaction is essential for many biological processes. The water structure at the
nonionic lipid interface remains little known, and there is no scope of a priori prediction of …

Structural and transport properties of lipid bilayers consisting of pure ceramides are
investigated through molecular dynamics simulations. Two different initial configurations are …

Stratum corneum (SC), the outermost layer of skin, is the main rate limiting step in
percutaneous absorption and the inter-corneocyte lipid matrix is the dominant pathway for …