Humans consider themselves discrete autonomous organisms, but recent research is
rapidly strengthening the appreciation that associated microorganisms make essential …

As human life expectancy is prolonged, age-related diseases are thriving. Aging is a
complex multifactorial process of molecular and cellular decline that affects tissue function …

The sirtuins are a phylogenetically conserved family of NAD+-dependent protein
deacetylases that consume one molecule of NAD+ for every deacetylated lysine side chain …

It is established that glucose restriction extends yeast chronological and replicative lifespan,
but little is known about the influence of amino acids on yeast lifespan, although some …

The anti-aging activity of many plant flavonoids, as well as their mechanisms of action, have
been explored in the current literature. However, the studies on the synergistic effects …

Altered mitochondrial function is tightly linked to lifespan regulation, but underlying
mechanisms remain unclear. Here, we report the chronological and replicative lifespan …

Here we show that in aging Saccharomyces cerevisiae (budding yeast) cells, NH4+ induces
cell death associated with shortening of chronological life span. This effect is positively …

Chronological aging of budding yeast cells results in a reduction in subsequent replicative
life span through unknown mechanisms. Here we show that dietary restriction during …

The traditional view on dietary restriction has been challenged with regard to extending
lifespan of the fruit fly Drosophila melanogaster. This is because studies have shown that …

A body of evidence supports the view that the signaling pathways governing cellular aging-
as well as mechanisms of their modulation by longevity-extending genetic, dietary and …