The highly conserved Notch signalling pathway functions in many different developmental
and homeostatic processes, which raises the question of how this pathway can achieve …

A revolution in cellular measurement technology is under way: For the first time, we have the
ability to monitor global gene regulation in thousands of individual cells in a single …

A common theme in the self-organization of multicellular tissues is the use of cell-cell
signaling networks to induce morphological changes. We used the modular synNotch …

The study of how cells interact to produce tissue development, homeostasis, or diseases
was, until recently, almost purely experimental. Now, multi-cell computer simulation …

Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics
for undergraduate or graduate students. It maps the huge and complex landscape of cell …

Abstract The Notch–Delta signalling pathway allows communication between neighbouring
cells during development. It has a critical role in the formation of 'fine-grained'patterns …

Although fluctuating asymmetry has become popular as a measure of developmental
instability, few studies have examined its developmental basis. We propose an approach to …

Chaste—C ancer, H eart A nd S oft T issue E nvironment—is an open source C++ library for
the computational simulation of mathematical models developed for physiology and biology …

Waddington's epigenetic landscape is probably the most famous and most powerful
metaphor in developmental biology. Cells, represented by balls, roll downhill through a …

The coordinated behaviour of populations of cells plays a central role in tissue growth and
renewal. Cells react to their microenvironment by modulating processes such as movement …