Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles' heel for the TB-causing pathogen
A Maitra, T Munshi, J Healy, LT Martin… - FEMS microbiology …, 2019 - academic.oup.com
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis,
remains one of the leading causes of mortality across the world. There is an urgent …
remains one of the leading causes of mortality across the world. There is an urgent …
[HTML][HTML] Antibiotics and resistance: the two-sided coin of the mycobacterial cell wall
Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is the global
leading cause of mortality from an infectious agent. Part of this success relies on the unique …
leading cause of mortality from an infectious agent. Part of this success relies on the unique …
Reaching toward underexplored targets in antibacterial drug design
The increase of antimicrobial resistance necessitates the renewal and strong research
involvement in antibacterial drug design. In the following work, we comment on the key …
involvement in antibacterial drug design. In the following work, we comment on the key …
Anti-tuberculosis Mur inhibitors: structural insights and the way ahead for development of novel agents
Mur enzymes serve as critical molecular devices for the synthesis of UDP-MurNAc-
pentapeptide, the main building block of bacterial peptidoglycan polymer. These enzymes …
pentapeptide, the main building block of bacterial peptidoglycan polymer. These enzymes …
Opportunities for overcoming tuberculosis: Emerging targets and their inhibitors
Tuberculosis (TB), an airborne infectious disease mainly caused by Mycobacterium
tuberculosis (Mtb), remains a leading cause of human morbidity and mortality worldwide …
tuberculosis (Mtb), remains a leading cause of human morbidity and mortality worldwide …
The mur enzymes chink in the armour of Mycobacterium tuberculosis cell wall
Tuberculosis (TB) transmitted by Mycobacterium tuberculosis (Mtb) is one of the top 10
causes of death globally. Currently, the widespread occurrence of resistance toward Mtb …
causes of death globally. Currently, the widespread occurrence of resistance toward Mtb …
The VAO/PCMH flavoprotein family
TA Ewing, MW Fraaije, A Mattevi… - Archives of Biochemistry …, 2017 - Elsevier
The VAO/PCMH flavoprotein family consists of structurally homologous flavin-dependent
enzymes that catalyze a wide range of chemical reactions. Family members share an …
enzymes that catalyze a wide range of chemical reactions. Family members share an …
Repurposing of FDA-approved drugs to target MurB and MurE enzymes in Mycobacterium tuberculosis
J Rani, Y Silla, K Borah, S Ramachandran… - Journal of …, 2020 - Taylor & Francis
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) is one amongst the top 10
causes of death worldwide. The growing rise in antibiotic resistance compounded with slow …
causes of death worldwide. The growing rise in antibiotic resistance compounded with slow …
Structure-based inhibitor screening of natural products against NSP15 of SARS-CoV-2 revealed thymopentin and oleuropein as potent inhibitors
R Vijayan, S Gourinath - Journal of proteins and proteomics, 2021 - Springer
Coronaviruses are enveloped, non-segmented positive-sense RNA viruses with the largest
genome among RNA viruses. Their genome contains a large replicase ORF which encodes …
genome among RNA viruses. Their genome contains a large replicase ORF which encodes …
[HTML][HTML] Screening and molecular dynamics simulation of compounds inhibiting MurB enzyme of drug-resistant Mycobacterium tuberculosis: An in-silico approach
Mycobacterium tuberculosis (MTB) is becoming more and more resistant to drugs and it is a
common problem, making current antimicrobials ineffective and highlighting the need for …
common problem, making current antimicrobials ineffective and highlighting the need for …