Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the
pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose …

White adipose tissue (WAT) is an endocrine organ highly integrated in homeostasis and
capable of establishing ways of communicating and influencing multiple metabolic …

Knowledge of immune cell phenotypes in the tumor microenvironment is essential for
understanding mechanisms of cancer progression and immunotherapy response. We …

Adipose tissue depots can exist in close association with other organs, where they assume
diverse, often non-traditional functions. In stem cell-rich skin, bone marrow, and mammary …

Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …

In mammals, white adipose tissues are largely divided into visceral epididymal adipose
tissue (EAT) and subcutaneous inguinal adipose tissue (IAT) with distinct metabolic …

Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

Graves orbitopathy, also known as thyroid eye disease or thyroid-associated orbitopathy, is
visually disabling, cosmetically disfiguring and has a substantial negative impact on a …

Cardiovascular diseases (CVDs) contribute to a large part of worldwide mortality. Similarly,
two of the major risk factors for these diseases, aging and obesity, are also global problems …

Accumulation of excess white adipose tissue (WAT) has deleterious consequences for
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …