The microbiome can be defined as the sum of the microbial and host's genome. Recent
information regarding this complex organ suggests that in animal models of multiple …

The classical paradigm of tuberculosis (TB) immunity, with a central protective role for Th1
responses and IFN-γ-stimulated cellular responses, has been challenged by unsatisfactory …

The efficacy of B cell depletion therapy in multiple sclerosis indicates their central
pathogenic role in disease pathogenesis. The B lymphotropic EBV is a major risk factor in …

Abstract CD40 interacts with CD40L and plays an essential role in immune regulation and
homeostasis. Recent research findings, however, support a pathogenic role of CD40 in a …

Introduction: In the past decade, the role of B cells in the pathogenesis of multiple sclerosis
(MS) is coming to the forefront. Depletion of B cells by anti-CD20 monoclonal antibodies …

Introduction. Multiple sclerosis (MS) is the most common neurological disease responsible
for early disability in the young working population. In the last two decades, based on …

Background: Multiple sclerosis (MS) is thought to be T cell mediated but the mechanisms
eliciting such a dysregulated adaptative immune response remain enigmatic. Objective: To …

In the broad field of autoimmunity and clinical immunology, experimental evidence over the
past few years have demonstrated several connections between the immune system and the …

Multiple sclerosis (MS) is an autoimmune disorder where both T cells and B cells are
implicated in pathology. However, it remains unclear how these two distinct populations …

The role of B cells in viral myocarditis (VMC) remains controversial. In order to establish a
role and mechanism of action for B cells in acute VMC, we established an acute VMC mouse …