The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

Cytokine signaling represents one of the cornerstones of the immune system, mediating the
complex responses required to facilitate appropriate immune cell development and function …

Background Our previous study has identified a novel circRNA (circDIDO1) that is down-
regulated in gastric cancer (GC) and significantly inhibits GC progression. The purpose of …

Epithelial to mesenchymal transition (EMT) is a biological process that plays an important
role during embryonic development. During this process, the epithelial cells lose their …

Abstract N6‑methyladenosine (m6A) RNA modification maintained by N6‑
methyltransferases and demethylases is involved in multiple biological functions …

Accurate cancer cell identification and efficient therapy are extremely desirable and
challenging in clinics. Here, we reported the first example of DNA tetrahedron …

Abstract N 6-Methyladenosine (m6A) is the most prevalent epigenetic RNA modification and
is vital in regulating malignancies. The roles of m6A modifiers on noncoding RNAs have not …

The tumor microenvironment (TME) comprises a variety of immune cells, among which T
cells exert a prominent axial role in tumor development or anti-tumor responses in patients …

Introduction Breast cancer (BC) is the most frequent malignant disease in women worldwide
and is therefore challenging for the healthcare system. Early BC detection remains a leading …

Tumours adapt to increasingly potent targeted therapies by transitioning to alternative
lineage states. In prostate cancer, the widespread clinical application of androgen receptor …